Contents

Russian Journal of Bioorganic Chemistry

Vol. 51, No. 5, 2025

Editorial Notes

Memorial Issue Dedicated to the 50th Anniversary of the Department of Bioorganic Chemistry, Faculty of Biology, Lomonosov Moscow State University

p. 1825  abstract

REVIEW PAPER

Modern Laboratory Test-Systems as Platforms for Validation of Clinically Promising T-Cell Receptors

R. V. Mungalov, N. S. Vand, D. M. Chudakov, and E. A. Bryushkova p. 1827  abstract

Discovery and Identification of Plant Regulatory Peptides

A. Yu. Skripnikov, E. E. Vorobeva, M. E. Taliansky, and N. O. Kalinina p. 1838  abstract

RNA Interference as a Method for Validation of Pharmacological Targets in Fibrosis Treatment

A. S. Mikaelyan, N. Halimani, V. V. Fedorova, and Yu. V. Kotelevtsev p. 1853  abstract

Small Noncoding RNAs are Global Regulators of Bacterial Life Cycle

Y. V. Skvortsova, A. S. Grigorov, O. S. Bychenko, and T. L. Azhikina p. 1863  abstract

Nonclassical Cannabinoid Receptors: Modern Concepts of Signal Transmission Functions and Mechanisms

M. G. Akimov, N. M. Gretskaya, and V. V. Bezuglov p. 1879  abstract

8-Oxo-2′-Deoxyguanosine: Oxidative Stress Control

N. V. Marmiy and D. S. Esipov p. 1909  abstract

RESEARCH PAPER

Proinflammatory Phenotype of CD161+ Double-Negative T Cells

I. V. Bogdanov and T. V. Ovchinnikova p. 1917  abstract

Improved Efficiency of OX40L-Based Gene Therapy Using a Non-Viral Delivery System in Fibroblast-Enriched Mouse Tumor Models

V. V. Pleshkan, M. V. Zinovyeva, D. A. Didych, and I. V. Alekseenko p. 1927  abstract

Molecular Probes for the Visualization of Nicotinic Acetylcholine Receptors Based on Snake Three-Finger Toxins and Red Fluorescent Protein

A. I. Kuzmenkov, I. S. Chudetsky, D. S. Kudryavtsev, I. E. Kasheverov, V. I. Tsetlin, and A. A. Vassilevski p. 1936  abstract

Cytoskeletal Regulator Zyxin Stimulates Nuclear Translocation of YAP in Xenopus laevis Embryonic Cells

E. A. Parshina, E. E. Orlov, E. E. Voronezhskaya, N. Yu. Martynova, and A. G. Zaraisky p. 1945  abstract

Targeted Nanoliposomes Loaded with IR780 Dye as a Multifunctional Nanoplatform for Photothermal and Photodynamic Cancer Therapy

G. M. Proshkina, E. I. Shramova, A. S. Sogomonyan, and S. M. Deyev p. 1954  abstract

Influence of Cultivation Conditions on Expression of Transcription Factor Genes in Glioblastoma Cells

A. I. Rezekina, D. V. Mazur, M. I. Shakhparonov, and N. V. Antipova p. 1962  abstract

Effect of STK11 Mutation in the LLC1 Mouse Lewis Lung Anedonacrcinoma Line on Sensitivity to Particle Radiotherapy

E. A. Gantsova, I. V. Arutyunyan, A. G. Soboleva, K. M. Shakirova, E. Yu. Kananykhina, D. V. Balchir, P. A. Vishnyakova, V. O. Saburov, K. B. Gordon, and T. Kh. Fathkudinov p. 1970  abstract

An Ionizable Cationic Lipid for Intracellular RNA Delivery

K. Sh. Gaisin, E. V. Ryabukhina, D. O. Koroev, I. I. Mikhalyov, E. S. Zhuravlev, G. A. Stepanov, I. A. Boldyrev, and E. L. Vodovozova p. 1982  abstract

Transcriptome Analysis of Zyxin Cytoskeletal Protein Levels: Influence on Metabolism and Signaling Pathways in a Model of Xenopus laevis Embryos

E. A. Parshina, A.G. Zaraisky, and N.Y. Martynova p. 1990  abstract

Changes in the Protein Composition of the Exiguobacterium sibiricum Membrane with Decreasing Temperature: A Proteomic Analysis

L. E. Petrovskaya, R. H. Ziganshin, E. A. Kryukova, E. V. Spirina, E. M. Rivkina, S. A. Siletsky, D. A. Dolgikh, and M. P. Kirpichnikov p. 2000  abstract

NLS Peptide Improves the Efficiency of pDNA Delivery into Eukaryotic Cells Mediated by Cationic Liposomes

E. V. Shmendel, O. V. Markov, M. A. Zenkova, and M. A. Maslov p. 2014  abstract

Construction of a Producer Strain of the Fibrinolitic Enzyme PAPC Based on Pichia pastoris Yeast

S. K. Komarevtsev, Yu. S. Lapteva, R. H. Ziganshin, V. V. Farofonova, V. N. Stepanenko, A. A. Osmolovskiy, K. A. Miroshnikov, and E. V. Loktyushov p. 2022  abstract

Development of an Experimental Intracranial PDX Model of Human Glioblastoma in NSG Mice

N. V. Antipova, D. A. Bondarenko, D. V. Mazur, A. A. Isakova, M. E. Gasparian, O. I. Patsap, V. M. Pavlov, E. S. Mikhailov, N. A. Goryacheva, D. I. Rzhevsky, S. G. Semushina, D. A. Dolgikh, A. N. Murashev, and A. V. Yagolovich p. 2034  abstract

Oral Indole-3-acetate Supplementation Increases the Abundance of Bifidobacterium pseudolongum and Akkermansia muciniphila in the Intestine of Mice on a High-Fat Diet

O. P. Shatova, A. A. Zabolotneva, S. A. Rumyantsev, and A. V. Shestopalov p. 2041  abstract

Properties of Potassium Channel Kv1.1 on the Basis of Fluorescent Dimer of Alpha-Subunits mKATE2-Kv1.1-Kv1.1 in Neuro-2a Cells

A. V. Efremenko, E. V. Kryukova, O. V. Kazakov, M. P. Kirpichnikov, O. V. Nekrasova, and A. V. Feofanov p. 2055  abstract

Three-Finger Viper Toxins: cDNA Cloning and Expression in E. coli Using a Chimeric (Hybrid) Construction with a SUMO Fusion Partner Protein

D. A. Sukhov, L. O. Ojomoko, I. V. Shelukhina, M. V. Vladykina, V. Yu. Kost, R. Kh. Ziganshin, O. V. Geraskina, S. V. Balandin, T. V. Ovchinnikova, V. I. Tsetlin, and Yu. N. Utkin p. 2064  abstract

Development of a Bacterial Expression System for Producing 15N/13C-Labeled Neuroglobin and Cytochrome C

M. A. Semenova, O. M. Smirnova, V. V. Britikov, E. V. Britikova, A. P. Khodnenko, Y. V. Bershatskii, A. A. Ignatova, E. V. Bocharov, M. P. Kirpichnikov, D. A. Dolgikh, and R. V. Chertkova p. 2077  abstract

Study of the Antiproliferative Activity of a Humanized Antibody to the Cancer-Testis Antigen PRAME

M. V. Larina, Yu. P. Finashutina, N. A. Kravchuk, V. A. Misyurin, V. N. Novoseletsky, D. S. Balabashin, O. N. Solopova, D. V. Sokolova, V. S. Pokrovsky, D. A. Dolgikh, T. K. Aliev, A. V. Misyurin, and M. P. Kirpichnikov p. 2089  abstract

REVIEW PAPER

Role of Different Isoniazid Analogs as Antitubercular Agents

S. Alghamdi, N. F. Qusty, S. M. Alghamdi, A. S. Dablool, S. Verma, and M. Asif p. 2100  abstract

RESEARCH PAPER

Rich Phenolic Structure of Flavone Glycosides and Feruloylquinic Acid: Evaluation of Their Bioactivity in the Natural Plant Acer palmatum var. amoenum

L. Zhao, D. Jiang, C. Shen, and F. Jin p. 2118  abstract

Synthesis, Spectral Characterization, In Vitro and In Silico Studies of Pyridinyl Pyrazole Carboxamide Derivatives

Munusamy Sasikala, E. Revathi, Rajendran Sribalan, and C. T. Ravichandran p. 2127  abstract

The Antibacterial Activity, Acute Toxicity, and Antibacterial Mechanism of 2,6-Dimethyl-4-aminophenol Hydrochloride

Kezhuang Wang, Chuanjin Wang, and Chengguo Sun p. 2142  abstract

Synthesis of Formononetin Derivatives and Their Protective Effects Against Oxidative Stress

Zeping Luo and Liwei Pan p. 2152  abstract

Synthesis, In Vitro and In Vivo Antifungal Activities of Novel Coumarin–Tryptophan Conjugates

Neha Tiwari, Ankita Kumari, Saurabh Sharma, Vaishali Raghuvanshi, Gunjan Uttam, Vineeta Singh, Karuna Singh, and Diksha Katiyar p. 2170  abstract

Unveiling the Antidiabetic Potential of 6-Chloro-3-(2-substituted-4-oxothiazolidin-3-yl)-2-phenylquinazolin-4(3H)-one Derivatives: Design, Synthesis, and Biological Evaluation Targeting Fructose 1,6-Bisphosphatase with In Silico ADMET and Docking Approaches

Sanjay D. Sawant and Vasundhara N. Sawant p. 2185  abstract

Synthesis and Antidiabetic Screening of Chalcone-Based N-Acetyl Pyrazoles

N. Iqbal, W. Rehman, O-U-R Abid, L. Rasheed, H. Sarfaraz, Y. Khan, A. F. AlAsmari, F. Alasmari, and M. Khan p. 2205  abstract

Neurochemical Protection of Lutein against Sodium Nitroprusside-Induced Oxidative Damage in the Nauphoeta cinerea Model

Carlos Alonso Leite dos Santos, Antonia Adeublena de Araújo Monteiro, Luiz Marivando Barros, Waseem Hassan, Jean Paul Kamdem, Abid Ali, Mashal M Almutairi, and Mohammad Ibrahim p. 2217  abstract

Narrative Review

Coumarins as Emerging Agents in Neurodegenerative Disease Management

Atyaf Talal Mahmood, Islam Khalid Kamal, and Yasser Fakri Mustafa p. 2228  abstract

REVIEW PAPER

Antioxidant Profile of Anacardic Acid Derivatives and Their Effects on Oxidative Stress-Induced Diseases: An Update

Priyabrata Pattanayak and Kamini Sethy p. 2247  abstract

RESEARCH PAPER

Synthesis, Anticancer and EGFR Inhibitory Activity of Novel Benzo[b][1,4]oxazine-1,3,4-oxadiazolo-1,2,3-triazoles

Vishweshwar Punna, Jeshma Kovvuri, Y. Umeshwar, and Maheshwar Kundarapu p. 2261  abstract

New Coumarin Hybrids from Chloramphenicol: A Step Towards Next-Generation Biocompatible Antimicrobials

Yasser Fakri Mustafa p. 2274  abstract

Synthesis, Biological Evaluation, and Computational Studies of Pyridine-Thiazolyl Hydrazones as Anticancer Candidates Targeting EGFR Kinase

Sonali S. Shinde, Jaydeo T. Kilbile, Sachin S. Bhusari, and Pravin S. Wakte p. 2288  abstract

REVIEW PAPER

Bioactive Coumarins: Bioorganic Strategies for Targeting Enzymes, Receptors, and DNA

Yasser Fakri Mustafa p. 2304  abstract