8-Oxo-2′-Deoxyguanosine: Oxidative Stress Control

Abstract— 8-Oxo-2′-deoxyguanosine is a well-known marker of oxidative stress. Research over the past decade suggests that this compound is probably not a byproduct of oxidative DNA damage, but an important bioregulator driving the cellular response to stress. This review collected and analyzed data on the participation of 8-oxo-2′-deoxyguanosine in the processes of mutagenesis, DNA repair, and regulation of gene expression, inflammatory responses, adaptive stress response, apoptosis, and cellular transformation. Particular attention is paid to the potential of 8-oxo-2′-deoxyguanosine as a therapeutic agent for the treatment of inflammatory, autoimmune, degenerative, and oncological diseases, as well as of traumatic and toxic injuries.