Contents

Russian Journal of Bioorganic Chemistry

Vol. 51, No. 6, 2025

A COMPREHENSIVE REVIEW

Importance of Dibenzoazepine and Azepine Derivatives in the Field of Medicinal Chemistry

Mahesh Bhat, J. Rangaswamy, S. V. Mamatha, T. Vishwanath, Mahima Samanth, and Roopa Nayak p. 2337  abstract

REVIEW PAPER

A Review on the Synthesis and Biological Significance of Oxadiazole (OXD) Derivatives: Sustainable Green Approaches and Applications

Preeti Shrivastava, Bontha Venkata Subramanya Lokesh, Soundarajan Krishnan, and Gautam M. Patel p. 2351  abstract

Quinoline Derivatives as Versatile Scaffold for Anti-Inflammatory Drug Development

K. Deepthi, S. Rutuja, Jennifer Fernandes, and Manjunath S. Katagi p. 2370  abstract

Coumarins as Bioorganic Building Blocks in Drug Design, Biocatalysis, and Sensing

Yasser Fakri Mustafa p. 2390  abstract

Clinically Significant Panallergens: Role in Sensitization and Diagnostic Approaches

S. Yu. Petrova, S. V. Khlgatian, V. M. Berzhets, L. N. Nesterenko, G. I. Alatortseva, and P. V. Samoilikov p. 2417  abstract

RESEARCH PAPER

Synthesis and Screening of 1-Methylisatin-linked 1,2,3-Triazoles as VEGFR-2 Inhibitors and Their Molecular Docking Studies

Prasad Pinnoju, Vijaya Lakshmi Bommidi, Sadanandam Kudikala, Manasa Scandakashi, Madavi Ramesh, and Sarasija Madderla p. 2432  abstract

Anti-Invasion and Apoptotic Induction Effects of Quercetin-Functionalized Silver Oxide (Ag2O) Nanoparticles on DU-145 Prostate Carcinoma Cells via Modulation of miR-34a, miR-181a, and Their Potential Targets

S. M. Mousavi Eshkelani, A. Sejdeh Hassankiadeh, M. Hajitabar, Z. Shamsi Balasbaneh, T. Kazemi, H. Beheshti Dafchahi, M. Shahriarinour, M. Nikpassand, N. Ranji, and R. S. Varma p. 2443  abstract

Assessment of Adaptive Immune Response Against Influenza Using Synthetic Peptides

О. V. Gribovskaya, A. M. Tsygankov, V. P. Martinovich, and V. V. Yanchenko p. 2455  abstract

Mono- and Dihydrazones with a 6-Methyluracil Fragment: Synthesis, Cytotoxicity and Antioxidant Activity

I. B. Chernikova, R. Yu. Khisamutdinova, N. S. Makara, E. R. Sayakhova, D. V. Ishmetova, and V. A. Vakhitov p. 2465  abstract

Synthesis, Characterization, and Biological Activity of Benzothiazole Thioether Derivatives

C. Kiran Yadav, B. Manjunatha, and B. P. Nandeshwarappa p. 2476  abstract

Heterocyclic Coumarin Derivatives as Multifunctional Biosafe Candidates: Bridging Synthetic Chemistry with In Vitro and In Silico Evaluations

Nameer Mazin Zeki, Yasser Fakri Mustafa, and Rana Naeem Jibroo p. 2482  abstract

Features of Synthesis and Study of Toxic Properties of Tryptophan-Containing Analogue of Arginine-Vasopressin

K. U. Baradzina, E. I. Kvyatkovskaya, V. P. Martinovich, O. V. Gribovskaya, O. V. Panibrat, T. V. Chukarina, S. E. Ogurtsova, R. D. Zilberman, O. N. Savanets, L. M. Olgometz, A. O. Savin, I. V. Zhebrokova, and E. V. Kravchenko p. 2508  abstract

Spatial Structure of the C-Terminal Domain of Bacillus cereus Hemolysin II is Stabilized in the Full-Size Toxin

N. V. Rudenko, B. S. Melnik, A. P. Karatovskaya, A. S. Nagel, Zh. I. Andreeva-Kovalevskaya, A. V. Zamyatina, O. S. Vetrova, A. V. Siunov, F. A. Brovko, and A. S. Solonin p. 2519  abstract

Molecular Interactions and Pharmacological Evaluation of Quinoline-Imidazole Derivatives: an In Vitro and In Silico Approach

Nagarjuna Prakash Dalbanjan, Lokesh Bheemayya, Arihant Jayawant Kadapure, Manjunath P. Eelager, Ravindra R. Kamble, and S. K. Praveen Kumar p. 2531  abstract

Treatment of Diabetes and Diabetes-Induced Cataracts as PPAR-γ Agonist and ALR2 Inhibitor by Synthesized Chalcones via In Silico, In Vitro and In Vivo Approaches

Ravindra M. Gol, Mitesh Patel, Vijaykumar M. Barot, Nilesh J. Patel, and Taslimahemad T. Khatri p. 2549  abstract

New Conjugates of 3′-Azido-3′-deoxythymidine and 2′,3′-Dideoxy-3′-thiacytidine Based on 1,3-(Dipalmitoylamino)propan-2-ol: Synthesis and Investigation of Anti-HIV Activity on Model Cellular Systems

E. S. Darnotuk, A. E. Sinyavin, M. N. Chudina, and N. S. Shastina p. 2565  abstract

Three-Dimensional Structure of the Orange-Red Fluorescent Biomarker DiB3-F53L

A. V. Rossohin, I. V. Artemiev, S. F. Arkhipova, V. Z. Pletnev, and N. V. Pletneva p. 2577  abstract

Synthesis of Dehydroabietic Acid Derivatives with 1,2,3-Triazole Substituents and Their Antiproliferative Activity against HeLa, MCF-7, and HEK-293T Cells

Yong Wang, Li-Na Liu, Shang-Hua Wei, Wei Wang, Cong-Jun Liu, Song Gao, Shu-Ping Yu, Ning Yao, and Yu-Fei Wang p. 2582  abstract

One-Pot Multicomponent Synthesis of Uracil Derivatives and Their Antiviral Activity

K. Jain, S. Sharma, A. Sharma, and D. Utreja p. 2593  abstract

Determination of IgG and IgA Antibodies by Fluorescence Polarization Using Fluorescently Labeled Recombinant Nanobodies

L. I. Mukhametova, S. A. Eremin, I. V. Mikhura, O. S. Goryainova, T. I. Ivanova, and S. V. Tillib p. 2602  abstract

Kaede Protein Chromophore Analogue as a Tool for Simultaneous Selective Staining of the Nucleus and Mitochondria

D. I. Rudik, A. R. Gilvanov, M. S. Baranov, and Yu. A. Bogdanova p. 2615  abstract

Design and Synthesis of a Novel Indole Derivative (2Cl-5N-ind-dione) and its Effect on miR-181a, miR-200a, and miR-34a Expression, Targeting Apoptosis, and Migration Pathways in HT-29 Colorectal Cancer Cells

M. Rasaei, E. Mohajeri, A. Sahranavard Siahmazgi, S. Nezamivand Chegini, S. Dabirian, H. Zahmatkesh, H. S. Kamalifar, B. Rasti, M. Shahriarinour, N. Ranji, and M. Nikpassand p. 2621  abstract

Synthesis and Biological Evaluation of N-1 Alkylated Isoindigo Derivatives: Antimicrobial, Antinematicidal, and Acetylcholinesterase Inhibition for Agrochemical Application

Gurbir Kaur, Divya Utreja, Anu Kalia, Sukhjit Kaur, and Yadhu Suneja p. 2636  abstract

Analysis of the Protein-Protein Interaction of CREBBP, HTT, and KMT2D by Principal Components Method

I. I. Khegai, R. Gong, and V. M. Efimov p. 2652  abstract

Synthesis and Biological Properties of Pyridoxine Derivatives Containing 1,3-Oxazolidine-2-one Fragments

A. S. Akchurin, N. V. Shtyrlin, S. V. Sapozhnikov, E. S. Bulatova, M. N. Agafonova, T. R. Azmetov, R. M. Vafina, A. R. Kayumov, E. Yu. Trizna, D. R. Baidamshina, M. N. Mansurova, D. Yu. Grishaev, and Yu. G. Shtyrlin p. 2660  abstract

Design, Synthesis, LSD1 Inhibitory Activity, and Docking Studies of C-19 Acylamino-Functionalized Isosteviol Derivatives

Cong-Jun Liu, Shang-Yu Yang, Tian-Ci Li, Hui Wang, Yong Wang, Wei Wang, Bing-Chao Duan, Li-Na Liu, Yu-Ling Li, and Yu-Fei Wang p. 2688  abstract

Water-Solvated SNAr Synthesis of N-(3-Substituted-phenyl)-4,6-dimethoxypyrimidin-2-amine Derivatives as Potent A549 Inhibitors: Anticancer and Molecular Dynamics Studies

Ranjitsinh C. Dabhi, Unnati P. Patel, Devashish Mehta, Nandan Dixit, Saumya Patel, Rakesh M. Rawal, Vidhi A. Trivedi, Kuldeepsinh J. Rathod, and Jayesh J. Maru p. 2697  abstract

Synthesis and Antibacterial Activity of Ethynyl and Azido Derivatives of N4-Dodecylamino-2′-deoxycytidine

D. A. Makarov, M. V. Jasko, I. L. Karpenko, E. V. Urbina, V. I. Popenko, O. G. Leonova, Y. V. Tkachev, B. F. Vasilyeva, O. V. Efremenkova, S. N. Kochetkov, and L. A. Alexandrova p. 2710  abstract

N4-(ω-Aminoalkyl)- and N4-(ω-Dansylaminoalkyl)-5-methyl-2′-deoxycytidines

D. A. Makarov, M. V. Jasko, I. L. Karpenko, Y. V. Tkachev, B. F. Vasilyeva, O. V. Efremenkova, S. N. Kochetkov, and L. A. Alexandrova p. 2719  abstract

Microwave-Assisted One-Pot Synthesis and Biological Evaluation of [1,2,3]Triazolo[1',5':1,5]pyrrolo[3,4-d]pyrimidines

Narahari Udayasree, G. Jyothi, Swathi Chirra, Uma Rani Janapatla, and Sirassu Narsimha p. 2725  abstract

Insight into New Quinoline-Pyrazole Hybrids as a Potential Xanthine Oxidase Inhibitor: Synthesis, Characterization, In Vitro and In Silico Studies

Pushpalatha Vodgalayya, Ramith Ramu, Deepthi Puttegowda, and Yeriyur Basavaiah Basavaraju p. 2737  abstract

Prospects for Determining Lactoferrin in Human Milk and Colostrum Using Immunological Diagnostic Methods

L. I. Mukhametova, S. A. Eremin, M. K. Kolokolova, Yu. S. Lebedin, I. V. Mikhura, O. V. Stetsiuk, T. I. Ivanova, and S. V. Tillib p. 2749  abstract

Synthesis of Novel Artesunate Derivatives by Multicomponent Reactions

A. A. Smirnova, E. V. Tretyakova, O. B. Kazakova, L. W. Hua, and S. Xiao p. 2763  abstract

Assessment of Toxicity, Genotoxicity and Cytotoxicity of Phenylcycloalkanpolycarboxylic Acids: A Study with Allium cepa and Chlorella vulgaris

A. A. Firstova, M. I. Kovaleva, E. R. Kofanov, and M. V. Tarasenko p. 2772  abstract

Solid-State Modification of Chitosan by Sorbic Acid

М. А. Khavpachev, I. V. Shelomentsev, P. L. Ivanov, Т. А. Akopova, V. V. Potseleev, G. P. Goncharuk, I. O. Kuchkina, M. Z. Bekanova, T. A. Cherdyntseva, and A. N. Zelenetskii p. 2781  abstract

Synthesis of New Phenothiazine Derivatives Bearing Triphenylphosphonium and F16 Cationic Groups in the 2-Alkyl Side Chain: Evaluation of Anticancer Activity and Mitochondrial Tropic Effects

A. Yu. Spivak, D. A. Nedopekina, E. V. Davletshin, A. D. Igoshkina, M. E. Astashev, U. Sh. Kuzmina, Y. V. Vakhitova, M. V. Dubinin, and K. N. Belosludtsev p. 2797  abstract

Fluorescently Labelled Cationic Liposomes with Sunitinib and the BODIPY-FL/L-Carnitine Conjugate for Theranostics

K. A. Afanasyeva, U. A. Budanova, Yu. L. Sebyakin, А. М. Gileva, M. G. Drozdova, and Е. A. Markvicheva p. 2812  abstract

Optimizing Scaffold Structures to Enhance DNAzyme-Based Nanomachine Activity in Double-Stranded DNA

M. Ateiah and M. S. Rubel p. 2823  abstract

Comparative Transcriptome Analysis of Two Related but Contrasting Quercus robur Genotypes under Drought Stress

T. S. Tikhomirova, V. G. Lebedev, E. O. Vidyagina, A. A. Popova, P. M. Evlakov, T. A. Grodetskaya, I. M. Nartova, V. S. Ryzhkova, and K. A. Shestibratov p. 2831  abstract

Transcription of Long Non-Coding RNAs in Cumulus Cells of the Cumulus-Oocyte Complex from Women with In Vitro Fertilization Failure

N. I. Enukashvily, A. R. Smolyaninova, I. A. Babenchuk, V. A. Gallyamova, K. O. Bashendjieva, N. V. Ponomartsev, J. A. Tatishcheva, and A. S. Kalugina p. 2852  abstract

Genomic Analysis of Antimicrobial Resistance Determinants in the Neisseria gonorrhoeae

E. A. Kochubei, Z. R. Zenchenko, and S. K. Dobrovolskii p. 2867  abstract

Erratum

Erratum to: Fabrication and Characterization of Piroxicam-Loaded Glycolated Chitosan-Stabilized Transdermal Patch

Sajid Raza, Muhammad Akhlaq, Aisha Siddiqua, Rukhshnda Habib, Khalid J. Alzahrani, Khalaf F. Alsharif, and Abul Kalam Azad p. 2878  abstract

Erratum to: Effect of STK11 Mutation in the LLC1 Mouse Lewis Lung Anedonacrcinoma Line on Sensitivity to Particle Radiotherapy

E. A. Gantsova, I. V. Arutyunyan, A. G. Soboleva, K. M. Shakirova, E. Yu. Kananykhina, D. V. Balchir, P. A. Vishnyakova, V. O. Saburov, K. B. Gordon, and T. Kh. Fathkudinov p. 2879  abstract

Erratum to: Enzymatic Synthesis and Molecular Docking Studies of Substituted 5-Phenyl-1,2,4-triazole-3-thione Deoxyribosides

I. V. Fateev, S. A. Sasmakov, A. A. Ziyaev, Zh. M. Abdurakhmanov, T. T. Toshmurodov, S. A. Ikramov, N. A. Tosheva, V. D. Frolova, E. A. Zorina, E. A. Zayats, B. Z. Eletskaya, O. S. Smirnova, M. Ya. Berzina, A. O. Arnautova, Yu. A. Abramchik, M. A. Kostromina, A. L. Kayushin, K. V. Antonov, I. A. Prokhorenko, A. S. Paramonov, V. L. Аndronova, R. S. Esipov, Sh. S. Azimova, A. I. Miroshnikov, and I. D. Konstantinova p. 2880  abstract