Contents

Russian Journal of Bioorganic Chemistry

Vol. 46, No. 6, 2020

Review

Functional Specifics of the MutL Protein of the DNA Mismatch Repair System in Different Organisms

M. V. Monakhova, M. A. Milakina, R. M. Trikin, T. S. Oretskaya and E. A. Kubareva p. 875  abstract

Review Article

Promising Molecular Targets for Design of Antitumor Drugs Based on Ras Protein Signaling Cascades

S. G. Klochkov, M. E. Neganova and Yu. R. Aleksandrova p. 891  abstract

Antibiotics from Extremophilic Micromycetes

A. A. Baranova, V. A. Alferova, V. A. Korshun and A. P. Tyurin p. 903  abstract

FFA1 (GPR40) Receptor Agonists Based on Phenylpropanoic Acid as Hypoglycemic Agents: Structure–Activity Relationship

S. O. Kuranov, O. A. Luzina and N. F. Salakhutdinov p. 972  abstract

Antitumor Activity of Selenium and Search Parameters for Its New Potentially Active Derivatives

P. A. Poluboyarinov, D. G. Elistratov and I. J. Moiseeva p. 989  abstract

The Hybrid Protein ZZ–OL as an Analytical Tool for Biotechnology Research

V. V. Krasitskaya, E. E. Bashmakova, A. N. Kudryavtsev, M. A. Vorobjeva, E. A. Shatunova and L. A. Frank p. 1004  abstract

Kv1 Potassium Channel Ligands Based on Hongotoxin 1 and Red Fluorescent Protein

A. L. Primak, M. A. Skutel, O. V. Nekrasova, A. S. Arseniev, M. P. Kirpichnikov and A. V. Feofanov p. 1011  abstract

Identification of Tumor Dissemination Facilitating Proteins in Exosomes Associated with Blood Cells of Breast Cancer Patients

O. S. Tutanov, K. V. Proskura, A. E. Grigor’eva, Yu. P. Tsentalovich and S. N. Tamkovich p. 1018  abstract

HLDF-6-Amide Reduces the Cytotoxicity of Doxorubicin and Activates the Proliferation of Tetrahymena pyriformis

O. Yu. Sokolov, A. N. Pozdnyakova, E. G. Cheremnykh, E. V. Vasileva, N. V. Kost and Y. A. Zolotarev p. 1034  abstract

Effect of the LKEKK Peptide on Human Keratinocytes

E. V. Navolotskaya, V. B. Sadovnikov, D. V. Zinchenko, Y. A. Zolotarev, V. M. Lipkin and A. N. Murashev p. 1038  abstract

Investigation of the Hydrolytic Stability of the HLDF-6-AA Antitumor Peptide by the Method of Accelerated Aging

Yu. A. Zolotarev, A. K. Dadayan, V. S. Kozik, I. Yu. Nagaev, V. N. Azev, E. Yu. Gorbunova, L. G. Mustaeva, A. P. Bogachouk, V. M. Lipkin and N. F. Myasoedov p. 1044  abstract

Development of a Pilot Technology for the Production of the Recombinant Human Enteropeptidase Light Chain in Soluble and Immobilized Forms

D. A. Makarov, A. A. Zinchenko, V. N. Stepanenko, D. S. Kalinin, T. D. Melikhova, E. A. Nokel, M. E. Gasparyan, I. V. Myagkih and D. A. Dolgikh p. 1052  abstract

Synthesis of (3R,10R)- and (3S,10S)-Diastereomers of 3,10-Dimethylspermine

M. A. Khomutov, M. T. Hyvönen, A. I. Salikhov, A. O. Chizhov, I. M. Ryzhov, S. N. Kochetkov, J. Vepsäläinen, T. A. Keinänen and A. R. Khomutov p. 1061  abstract

“Double” Pyrimidine Derivatives: Synthesis and Primary Assessment of Hepatoprotective Properties In Vitro

A. B. Vyshtakalyuk, V. E. Semenov, A. A. Parfenov, M. S. Shashyn, G. P. Belyaev, I. V. Galyametdinova and V. V. Zobov p. 1067  abstract

Synthesis of New Furanone Derivatives with Potent Anticancer Activity

W. H. Lashin, I. F. Nassar, A. F. El Farargy and A. O. Abdelhamid p. 1074  abstract

Synthesis and Evaluation of Novel Isoindoline-1,3-dione Derivatives as Anticancer Agents

M. A. A. Radwan, F. M. Alminderej, M. Premanathan, A. S. S. Alwashmi, F. A. Alhumaydhi, W. Alturaiki and S. A. Alsagaby p. 1087  abstract

Design, Synthesis, and Cytotoxic Screening of New Quinoline Derivatives over MCF-7 Breast Cancer Cell Line

Islam Zaki and Amal M. Imam p. 1099  abstract

Microwave-Assisted Synthesis and Molecular Docking Studies of Fluorinated 1,3,4-Oxadiazole Derivatives as Antimicrobial Agent

B. K. Dhotre, M. A. Patharia, A. U. Khandebharad, S. V. Raut and M. A. Pathan p. 1110  abstract

Synthesis, Cytotoxicity Evaluation, and Molecular Docking Studies of Novel Pyrrole Derivatives of Khellin and Visnagin via One-Pot Condensation Reaction with Curcumin

Nagwa M. Fawzy, Alaadin E. Sarhan, Eman A. Elhefny, Atiat M. Nasef and Magdy S. Aly p. 1117  abstract

Synthesis and Pharmacological Screening of Difluorophenyl Pyrazole Chalcone Conjugates as Antifungal, Anti-Inflammatory, and Antioxidant Agents

S. Y. Jadhav, N. A. Peerzade, M. G. Hublikar, B. D. Varpe, A. A. Kulkarni and R. B. Bhosale p. 1128  abstract

Synthesis and Anti-Proliferative Activity of New Acridinyl and Benzothiazolyl-Based Triazole Glycosides via Click Cycloaddition and Their Tetrazolyl Analogs

Hala E. M. Tolan, Mohamed A. A. Radwan, Hanan A. Soliman, Hanem M. Awad and Wael A. El-Sayed p. 1136  abstract

Docking Simulation and Anti-Inflammatory Profile of Some Synthesized Heterodimer of Pyrazole

Pratima Yadav, Ranjeet Kumar and Ashish Kumar Tewari p. 1148  abstract

Delivery of Barnase to Cells in Liposomes Functionalized by Her2-Specific DARPin Module

V. O. Shipunova, E. I. Shramova, A. A. Schulga, M. V. Shilova, S. M. Deyev and G. M. Proshkina p. 1156  abstract

Study of Interaction of Fluorescent Cytochrome C with Liposomes, Mitochondria, and Mitoplasts by Fluorescence Correlation Spectroscopy

I. D. Gusev, A. M. Firsov, R. V. Chertkova, E. A. Kotova, D. A. Dolgikh, M. P. Kirpichnikov and Y. N. Antonenko p. 1162  abstract

The Role of Maternal pou5f3.3/oct60 Gene in the Regulation of Initial Stages of Tissue Differentiation during Xenopus laevis Embryogenesis

E. A. Parshina, A. G. Zaraisky and N. Y. Martynova p. 1172  abstract

Effect of Hyperthermia on Proteases and Growth Regulators in the Skeletal Muscle of Cultivated Rainbow Trout O. mykiss

N. P. Kantserova, M. V. Churova, L. A. Lysenko, E. D. Tushina, M. A. Rodin, M. Yu. Krupnova and I. V. Sukhovskaya p. 1181  abstract

Lectin of the Bivalve Glycymeris yessoensis as a Pattern Recognition Receptor

T. O. Mizgina, I. V. Chikalovets, V. I. Molchanova, M. S. Kokoulin, A. P. Filshtein, E. V. Sidorin and O. V. Chernikov p. 1187  abstract

Interaction of SiFe Nanoparticles with Epithelial and Lymphoid Cells

N. V. Sharonova, E. V. Svirshchevskaya, A. A. Popov, N. V. Karpov, G. V. Tikhonovskiy, A. Yu. Zakharkiv, S. V. Sizova, V. Yu. Timoshenko, S. M. Klimentov and V. A. Oleinikov p. 1198  abstract

Negative Correlation between Natural Human Antibodies Directed to Glycotopes Galβ1-3GlcNAc and Galβ1-4GlcNAc

N. V. Shilova, I. M. Ryzhov, M. M. Ziganshina, A. S. Rakitko, M. E. Huflejt and N. V. Bovin p. 1207  abstract

Monoclonal Antibody HlyIIC‑15 to C-End Domain HlyII B. cereus Interacts with the Trombin Recognition Site

A. V. Zamyatina, N. V. Rudenko, A. P. Karatovskaya, A. O. Shepelyakovskaya, A. V. Siunov, Zh. I. Andreeva-Kovalevskaya, A. S. Nagel, V. I. Salyamov, A. S. Kolesnikov, F. A. Brovko and A. S. Solonin p. 1214  abstract

Production of Recombinant Allergens Phl p 1 and Amb a 1 for Detection of Class E Immunoglobulins

O. O. Mikheeva, M. A. Kostromina, D. D. Lykoshin, M. N. Tereshin, S. K. Zavriev, E. V. Svirshchevskaya, S. V. Khlgatyan and R. S. Esipov p. 1221  abstract

Increasing the Fluorescence Brightness of Superphotostable EGFP Mutant by Introducing Mutations That Block Chromophore Protonation

A. V. Mamontova, A. M. Shakhov, A. P. Grigoryev, K. A. Lukyanov and A. M. Bogdanov p. 1229  abstract

Delivery of CRISPR/Cas9 Ribonucleoprotein Complex into Plant Apical Meristem Cells Leads to Large Deletions in an Editing Gene

A. V. Khromov, A. V. Makhotenko, S. S. Makarova, T. P. Suprunova, N. O. Kalinina and M. E. Taliansky p. 1242  abstract

Uncharged Gemini-Amphiphiles as Components of Cationic Liposomes for Delivery of Nucleic Acids

E. V. Shmendel, S. A. Bakhareva, D. M. Makarova, I. V. Chernikov, N. G. Morozova, E. L. Chernolovskaya, M. A. Zenkova and M. A. Maslov p. 1250  abstract

Bacterial Production and Structural Study of Human Neuromodulator Lynx2

A. S. Paramonov, M. A. Shulepko, M. V. Kocharovskaya, A. E. Alenkin, A. O. Evdokimova, P. I. Akentiev, Z. O. Shenkarev, M. P. Kirpichnikov and E. N. Lyukmanova p. 1261  abstract

Are Levorin Channels with Selective Permeability Capable of Enhancing Muscle Activity in Complex with Carriers?

T. P. Taghi-zada and Kh. M. Kasumov p. 1270  abstract

Prediction of Antiglycation Activity by Calculating the Energies of Frontier Molecular Orbitals for New 4-Hydroxy-1,4-Dihydroazolo[5,1-c]-1,2,4-Triazines Used as an Example

R. A. Litvinov, R. A. Drokin, D. D. Shamshina, M. Yu. Kalenova, L. E. Usmianova, E. A. Muraveva, P. M. Vasiliev, E. K. Voinkov, E. N. Ulomskiy, A. A. Spasov and V. L. Rusinov p. 1278  abstract

Specific Features of Phase Transfer Catalytic Glycosylation of 2-Mercaptobenzimidazole

T. A. Chupakhina and V. O. Kur’yanov p. 1285  abstract

Letter to the Editor

6,7-Dialcoxy-Benzothiophene Derivatives as the Basis for Synthesis of Fluorescent Sensors for Reactive Oxygen Species

Ya. V. Bolt, A. S. Tsarkova and N. S. Baleeva p. 1289  abstract

Errata

Erratum to: Synthesis, Reactions, and Antimicrobial Activity of Novel Heterocyclic Compounds Containing Cyclopenta[d]thieno[2,3-b]pyridine Moiety and Related Fused Heterocycles

Remon M. Zaki, Adel M. Kamal El-Dean, Shaban M. Radwan and Mahmoud A. Ammar p. 1293  abstract