Contents

Russian Journal of Bioorganic Chemistry

Vol. 45, No. 6, 2019

Systems of Delivery of CRISPR/Cas9 Ribonucleoprotein Complexes for Genome Editing

R. N. Amirkhanov and G. A. Stepanov p. 431  abstract

Application of Natural Polysaccharides in Pharmaceutics

M. V. Khvostov, T. G. Tolstikova, S. A. Borisov and A. V. Dushkin p. 438  abstract

O-Specific Polysaccharides (O-Antigens) of a New Species of Enteric Bacteria Escherichia albertii Closely Related to Escherichia coli

O. I. Naumenko, S. N. Senchenkova and Yu. A. Knirel p. 451  abstract

C-Methylated Analogs of Spermine and Spermidine: Synthesis and Biological Activity

M. A. Khomutov, I. V. Mikhura, S. N. Kochetkov and A. R. Khomutov p. 463  abstract

Quorum Sensing Inhibition: Current Advances of the Natural Antimicrobial Agents

M. Asif and M. Imran p. 488  abstract

Monoclonal Antibodies to the Recombinant Protein VP7 of Bluetongue Virus

N. V. Rudenko, A. P. Karatovskaya, A. O. Shepelyakovskaya, A. V. Zamyatina, F. A. Brovko, A. Yu. Koltsov, I. R. Imatdinov, A. R. Imatdinov, O. M. Strijakova, K. A. Mima, V. M. Lyska and D. V. Kolbasov p. 505  abstract

Pharmacokinetics of HLDF-6-AA Peptide in the Organism of Experimental Animals

Yu. A. Zolotarev, A. K. Dadayan, V. S. Kozik, S. I. Shram, V. N. Azev, A. P. Bogachouk, V. M. Lipkin and N. F. Myasoedov p. 514  abstract

Preliminary Structural Characteristic of Polysaccharides Extracted From the Callus Tissue of Sosnowskyi’s Hogweed (Heracleum Sosnowskyi Manden) Stem by Aqueous Ammonium Oxalate

E. N. Gordina, S. P. Kuznetsov, V. V. Golovchenko and A. A. Zlobin p. 522  abstract

Effect of Sequestosome-1/p62 Expression on Autophagy of Human Periodontal Ligament Fibroblasts Induced by Porphyromonas gingivalis

Han Su, Yibo Zhang, Yongju Chen, Bingjun Fan, Bo Hao and Xin Li p. 528  abstract

Effect of Cys34 Oxidation State of Albumin on Its Interaction with Paraoxon according to Molecular Modeling Data

D. A. Belinskaia, M. A. Terpilovskii, A. A. Batalova and N. V. Goncharov p. 535  abstract

Synthesis and Antimicrobial and Antifungal Activity of Resin Acid Acetylene Derivatives

E. V. Tretyakova, E. V. Salimova and L. V. Parfenova p. 545  abstract

Synthesis and Cytotoxicity of Triterpenic Acids Modified at C3 and C28 Positions

E. F. Khusnutdinova, A. V. Petrova, O. B. Kazakova and A. E. Barmashov p. 552  abstract

Hepatoprotective Activity of Betulin and Dipterocarpol Derivatives

O. B. Kazakova, I. E. Smirnova, N. I. Medvedeva, T. V. Lopatina, I. V. Chudov, A. R. Sharipov, A. S. Ziganshin and Tran Thi Phuong Thao p. 558  abstract

Facile Synthesis of New Hybrid 2-Quinlolinone Derivatives Structures as Anticancer Drugs for Breast Cancer Treatment

Safyah B. Bakare p. 566  abstract

Synthesis and Biological Evaluation of Some Succinimide Hybrid Molecules

Fatih Yılmaz, Emre Menteşe and Nimet Baltaş p. 575  abstract

Synthesis and Biological Evaluation of Novel Steroidal 5α,8α-Endoperoxide Derivatives with Aromatic Hydrazone Side Chain as Potential Anticancer Agents

H. J. Wang, M. Bu, J. Wang, L. Liu and S. Zhang p. 585  abstract

Comparative Analysis of Nucleotide Fluorescent Analogs for Registration of DNA Conformational Changes Induced by Interaction with Formamidopyrimidine-DNA Glycosylase Fpg

A. A. Kuznetsova, O. A. Kladova, Nicolas P. F. Barthes, Benoit Y. Michel, Alain Burger, O. S. Fedorova and N. A. Kuznetsov p. 591  abstract

New Fluorescent Analogs of Nucleotides Based on 3-Hydroxychromone for Recording Conformational Changes of DNA

O. A. Kladova, A. A. Kuznetsova, Nicolas P. F. Barthes, Benoit Y. Michel, Alain Burger, O. S. Fedorova and N. A. Kuznetsov p. 599  abstract

Design and Visualization of DNA/RNA Nanostructures from Branched Oligonucleotides Using Blender Software

A. Yu. Bakulina, Z. V. Rad’kova, E. A. Burakova, E. Benassi, T. S. Zatsepin, A. A. Fokina and D. A. Stetsenko p. 608  abstract

Exploring the Interaction of Human Ribosomal Protein uS3 with Single-Stranded DNAs Having Different Sequences

A. S. Ochkasova, M. R. Kabilov, G. G. Karpova and D. M. Graifer p. 619  abstract

Relative Efficiency of Recognition of 5-Methylcytosine and 5-Hydroxymethylcytosine by Methyl-Dependent DNA Endonuclease GlaI

D. V. Petrova, M. B. Naumenko, D. V. Khantakova, I. R. Grin and D. O. Zharkov p. 625  abstract

Conformational Dynamics of Dioxygenase AlkB and DNA in the Course of Catalytically Active Enzyme–Substrate Complex Formation

L. Y. Kanazhevskaya, D. A. Smyshlyaev, I. V. Alekseeva and O. S. Fedorova p. 630  abstract

Platinum Polyoxoniobates Form Adducts with DNA

A. V. Yudkina, M. N. Sokolov, P. A. Abramov, I. R. Grin and D. O. Zharkov p. 641  abstract

Effective Inhibitors of Tyrosyl-DNA Phosphodiesterase 1 Based on Monoterpenoids as Potential Agents for Antitumor Therapy

A. A. Chepanova, N. S. Li-Zhulanov, A. S. Sukhikh, A. Zafar, J. Reynisson, A. L. Zakharenko, O. D. Zakharova, D. V. Korchagina, K. P. Volcho, N. F. Salakhutdinov and O. I. Lavrik p. 647  abstract

Synthesis of Random DNA Libraries for In Vitro Selection and Analysis of Their Nucleotide Composition

A. S. Davydova, O. A. Krasheninina, A. E. Tupikin, M. R. Kabilov, A. G. Venyaminova and M. A. Vorobyeva p. 656  abstract

New Oligodeoxynucleotide Derivatives Containing N-(Sulfonyl)-Phosphoramide Groups

E. A. Burakova, A. Sh. Derzhalova, B. P. Chelobanov, A. A. Fokina and D. A. Stetsenko p. 662  abstract

Algorithm for Searching and Testing the Activity of Antisense Oligonucleotides Exemplified by the mRNA of the rpoD Gene Encoding Staphylococcus aureus RNA Polymerase Sigma Factor

N. L. Mironova, M. S. Kupryushkin, Y. A. Khlusevitch, A. L. Matveev, N. V. Tikunova, D. V. Pyshnyi and M. A. Zenkova p. 669  abstract

Bridged Oligonucleotides with Smoothed Hybridization Properties as a Tool for Analysis of Nucleotide Sequences

I. A. Pyshnaya, A. A. Lomzov and D. V. Pyshnyi p. 677  abstract

Features of Determining Thermodynamic Parameters of Formation of Nucleic Acid Complexes Using Thermal Denaturation with Fluorimetric Signal Detection

G. Y. Shevelev, M. R. Kabilov, A. A. Lomzov, I. S. Dovydenko and D. V. Pyshnyi p. 684  abstract

Study of the Staudinger Reaction and Reveal of Key Factors Affecting the Efficacy of Automatic Synthesis of Phosphoryl Guanidinic Oligonucleotide Analogs

M. A. Bazhenov, A. V. Shernyukov, M. S. Kupryushkin and D. V. Pyshnyi p. 699  abstract

Physicochemical Properties of the Phosphoryl Guanidine Oligodeoxyribonucleotide Analogs

E. S. Dyudeeva, M. S. Kupryushkin, A. A. Lomzov, I. A. Pyshnaya and D. V. Pyshnyi p. 709  abstract

Targeted Delivery of Nucleic Acids by Folate-Containing Liposomes into KB-3-1 and HEK 293 Cells

E. V. Shmendel, T. O. Kabilova, N. G. Morozova, M. A. Zenkova and M. A. Maslov p. 719  abstract

Methods for Molecular Evolution of Polymerases

S. A. Zhukov, A. A. Fokina, D. A. Stetsenko and S. V. Vasilyeva p. 726  abstract

Incorporation of Antisense Oligonucleotides into Lipophilic Concatemeric Complexes Provides Their Effective Penetration into Cells

O. N. Gusachenko, O. A. Patutina, V. A. Gvozdev, M. I. Meschaninova, A. G. Venyaminova, V. V. Vlassov and M. A. Zenkova p. 739  abstract

Increase in Sensitivity of HEK293FT Cells to Influenza Infection by CRISPR-Cas9-Mediated Knockout of IRF7 Transcription Factor

A. B. Komissarov, M. V. Sergeeva, E. V. Mozhaeva, N. V. Eshchenko, A. D. Vasilieva, K. A. Vasilyev, S. P. Medvedev, A. A. Malakhova, E. A. Balakhonova, S. Yu. Malanin, T. V. Grigoryeva, E. S. Zhuravlev, D. V. Semenov, V. A. Richter and G. A. Stepanov p. 749  abstract

Mutations Preventing the Phosphorylation of Human Ribosomal Protein uS15 at Y38 and S48 Reduce the Efficiency of its Transfer into the Nucleolus

A. E. Vasilyeva, D. D. Yanshina, G. G. Karpova and A. A. Malygin p. 758  abstract

Investigation of the Internalization of Fluorescently Labeled Lipophilic siRNA into Cultured Tumor Cells

I. V. Chernikov, U. A. Karelina, M. I. Meschaninova, A. G. Ven’yaminova, M. A. Zenkova, V. V. Vlassov and E. L. Chernolovskaya p. 766  abstract

Antiviral Activity of a New Class of Chemically Modified Antisense Oligonucleotides against Influenza А Virus

A. V. Markov, M. S. Kupryushkin, E. P. Goncharova, R. N. Amirkhanov, S. V. Vasilyeva, D. V. Pyshnyi, M. A. Zenkova and E. B. Logashenko p. 774  abstract

Tumor Specific Peptides Selected for Targeted Delivery of Therapeutic Agents to Glioma Human Cells

A. A. Voitova, M. D. Dmitrieva, M. A. Dymova, N. S. Vasileva, A. A. Nushtaeva, V. A. Richter and E. V. Kuligina p. 783  abstract

RGD Peptide–Albumin Conjugate for Endothelization of Electrospun Materials

A. V. Cherepanova, D. Akisheva, T. V. Popova, B. P. Chelobanov, Yu. A. Chesalov, T. S. Godovikova, A. A. Karpenko and P. P. Laktionov p. 793  abstract

2'OMe Modification of Anti-miRNA-21 Oligonucleotide–Peptide Conjugate Improves Its Hybridization Properties and Catalytic Activity

S. K. Miroshnichenko, B. Amirloo, E. V. Bichenkova, V. V. Vlassov, M. A. Zenkova and O. A. Patutina p. 803  abstract

Novel Bisimidazole-Containing Peptidomimetic Molecules for Мetal-Independent RNA Cleavage: Synthesis and Solid-Phase Screening Method

A. S. Pavlova, P. A. Ogurtsova, L. S. Koroleva, I. Y. Serpokrylova, A. A. Lomzov, I. A. Pyshnaya, V. N. Silnikov and D. V. Pyshnyi p. 813  abstract

RNase P-Guiding Peptide Conjugates of Oligo(2'-O-methylribonucleotides) as Prospective Antibacterial Agents

N. A. Danilin, L. S. Koroleva, D. S. Novopashina and A. G. Venyaminova p. 825  abstract

Synthetic Antimicrobial Peptides. II. Antimicrobial and Hemolytic Activity of Cationic Peptides Containing Cysteine Residues with Free Sulfhydryl Groups

N. V. Amirkhanov, N. V. Tikunova and D. V. Pyshnyi p. 833  abstract

Letter to Editor

A New Approach for the Hybridization Analysis of Pathogens

E. V. Kostina, A. N. Sinyakov and V. A. Ryabinin p. 842  abstract