Contents

Russian Journal of Bioorganic Chemistry

Vol. 52, No. 4, 2026

RESEARCH PAPER

Biodiversity and Antimicrobial Activities of Bac7-Like Cathelicidins from Cetartiodactyls

P. V. Panteleev, I. A. Bolosov, O. V. Korobova, A. I. Borzilov, and T. V. Ovchinnikova p. 84  abstract

Therapeutic Potential and Mechanism of Action of a New Cathelicidin from the Chacoan Peccary (Catagonus wagneri)

I. A. Bolosov, V. N. Safronova, O. V. Korobova, A. I. Borzilov, T. V. Ovchinnikova, and P. V. Panteleev p. 85  abstract

Novel Imine Derivatives of 1,2,4-Triazole-3-thione: Synthesis, Characterization, Antimicrobial Activities, and ADME Profile Investigation

Palak I. Vaja, Mehul R. Chauhan, and Satish M. Ghelani p. 86  abstract

Synthetic Antimicrobial Peptides. VI. Antifungal Activity of Histidine-containing Peptides against Various Pathogenic and Opportunistic Species of Candida Fungi

N. V. Amirkhanov, A. V. Bardasheva, N. V. Tikunova, and V. N. Silnikov p. 87  abstract

Design and Synthesis of Structurally Tailored 4H-Pyran Derivatives as Potent Therapeutics for Precision Gastric Cancer Targeting

Shichao Yan, Zuojun Qu, Junpeng Chi, Zhe Xu, Aifeng Yang, Zhen Lv, and Hong Li p. 88  abstract

Synthesis, Docking, and Biological Properties of N- and O-Acyl Derivatives of 2-Aryl-substituted Quinolinecarboxylic Acids

N. Z. Hakobyan, A. S. Grigoryan, R. A. Madoyan, A. G. Sukiasyan, T. A. Ambartsumyan, M. Yu. Danghyan, A. A. Hambardzumyan, and A. A. Harutyunyan p. 89  abstract

Synthesis, Docking, and Biological Properties of 2-Phenyl-5,6,7,8-tetrahydroquinazoline-4(3H)-thione Derivatives

M. S. Safaryan, R. A. Madoyan, A. G. Sukiasyan, A. G. Ayvazyan, A. A. Mnatsakanyan, M. Yu. Danghyan, A. A. Hambardzumyan, and A. A. Harutyunyan p. 90  abstract

REVIEW PAPER

Unlocking the Therapeutic Potential of Heterocyclic Molecules as SIRT2 Inhibitors: Advancing Therapeutic Frontiers

Arti Soni, Vivek Kumar, Daisy Arora, Rohit Bhatia, and Neelam Malik p. 91  abstract

RESEARCH PAPER

Exosome-Derived miR-25-3p Inhibits Mitochondrial Damage by Targeting SOX4 and Attenuates Sepsis-Induced Myocardial Injury

Rong Huang, Jing Cao, Hongyan Zhao, Weirong Tao, and Chao Xu p. 92  abstract

Recombinant Proteins Containing Hepatitis C Virus Protein Epitopes Fused with One, Two, or Three Copies of a Lipopeptide Form Nanoparticles of Different Sizes and Differing in Immunological Properties

V. V. Kupriyanov, L. I. Nikolaeva, A. A. Zykova, M. D. Stuchinskaya, E. A. Blokhina, and N. V. Ravin p. 93  abstract

Synthetic Analogs of Ganglioside GD2 for the Study of Its Cluster and Multivalent Interactions with Antibodies

M. S. Sokolova, E. M. Rapoport, V. A. Zubricheva, R. V. Kholodenko, A. S. Paramonov, S. V. Khaidukov, N. V. Bovin, and I. M. Ryzhov p. 94  abstract

Albumin Nanoparticles as a Carrier System for the Delivery of the Antiarrhythmic Drug Amiodarone

A. V. Doroshchenko, A. D. Lapanik, P. D. Orlova, A. V. Lopukhov, I. M. Le-Deygen, Yu. I. Oshchepkova, Sh. I. Salikhov, and N. L. Klyachko p. 95  abstract

RESEARCH PAPER

Acylthioureas Based on Ursane-Type Amines: Synthesis and Study of Anti-Inflammatory and Cytotoxic Properties

S. A. Popov, T. D. Borisova, E. E. Shults, D.A. Kiseleva, M. K. Marenina, Yu. V. Meshkova, and T. G. Tolstikova p. 96  abstract

REVIEW PAPER

8-Oxo-2′-deoxyguanosine: From Oxidative Stress Marker to Epigenetic Regulator

V. G. Snyga, V. Yu. Savitskaya, E. S. Gromova, M. I. Zvereva, T. S. Oretskaya, and E. A. Kubareva p. 97  abstract

RESEARCH PAPER

Red Shift of the Absorption Maximum of Mutant Exiguobacterium sibiricum Proteorhodopsin: Influence of Amino Acid Substitutions in Helices E and F

L. E. Petrovskaya, E. P. Lukashev, E. A. Kryukova, D. A. Dolgikh, and M. P. Kirpichnikov p. 98  abstract

Co-Administration of mRNAs Encoding HA, M1, and NP Antigens of the Influenza Virus Leads to the Formation of Virus-Like Particles and an Enhanced Immune Response

O. V. Markov, M. V. Sergeeva, D. N. Shcherbakov, D. N. Antropov, E. P. Goncharova, E. S. Zhuravlev, A. S. Dome, A. S. Fomin, S. I. Gayvoronsky, K. S. Kudrya, A. A. Isaeva, E. A. Volosnikova, A. V. Chechushkov, E. V. Shmendel, P. A. Puchkov, Y. E. Poletaeva, E. S. Ryabova, M. A. Maslov, V. V. Koval, and G. A. Stepanov p. 99  abstract

REVIEW PAPER

Mutant Forms of Nucleoside Phosphorylases and Other Nucleic Acid Metabolism Enzymes for the Optimization of Cascade Synthesis of Modified Nucleosides

E. A. Zayats, Y. A. Abramchik, M. A. Kostromina, I. D. Konstantinova, and R. S. Esipov p. 100  abstract

RESEARCH PAPER

Alterations of Tryptophan Metabolism Pathways in Immunoglobulin A Nephropathy: an Exploratory Study

E. I. Savelieva, M. D. Shachneva, T. I. Alyushina, Z. K. Kochoyan, O. V. Galkina, and V. A. Dobronravov p. 101  abstract

Synthetic Transformations of Higher Terpenoids. 46. Synthesis and Cytotoxic Properties of 16-(1,2,4-Oxadiazolyl)lambertianic Acid Derivatives

Yu. V. Kharitonov, M. K. Marenina, Yu. V. Meshkova, T. G. Tolstikova, and E. E. Shults p. 102  abstract