Contents

Russian Journal of Bioorganic Chemistry

Vol. 51, No. 4, 2025

REVIEW PAPER

Recent Developments in Structurally Diverse Anti-Tubercular Drug Molecules and Their Molecular Targets Against Mycobacterium tuberculosis

S. Alghamdi, N. F Qusty, A. Maulana, M. Ajmal, M. Khan, A. K. Mahato, S. Verma, and M. Asif p. 1385  abstract

Harnessing Artificial Intelligence to Discover the Therapeutic Potential of Natural Coumarins: A Review Study

Nameer Mazin Zeki, and Yasser Fakri Mustafa p. 1432  abstract

Application of 3D Imaging in Biomedical Research

A. M. Safonov, A. V. Altunina, I. S. Kolpashnikov, D. O. Solovyeva, and V. A. Oleynikov p. 1453  abstract

BCR-ABL Inhibitors in the Targeted Therapy of Chronic Myeloid Leukemia

S. G. Kostryukov, O. A. Belyakova, D. V. Mishkin, D. V. Stulnikov, and A. V. Dektyarev p. 1471  abstract

RESEARCH PAPER

Synthesis, Biological Evaluation, and Molecular Docking Studies of Hexahydro-1H-xanthene-1,8(2H)-dione and 1,2,3-Triazole Hybrids as Potent Free Radical Scavengers

Jaydeep N. Lalpara, Bhavin B. Dhaduk, G. G. Dubal, Maneesh Kumar Gupta, Chandan Kumar Pashavan, Jayendra Kanzariya, Rakesh Rola, Mayur Shiyal, and Sanjay D. Hadiyal p. 1489  abstract

Design, Synthesis, and Biological Evaluation of Novel EZH2 Inhibitors

Dan Wang, Ming-Tao Xia, Xiang Li, Ru-Xing Wang, Ling Yu, and Shuai Li p. 1498  abstract

Solid-Phase PCR on Film Biochips with Brush Polymer Cells, “Lab-On-A-Chip”

I. Yu. Shishkin, K. А. Sinnikov, G. F. Shtylev, R. A. Miftakhov, O. A. Zasedateleva, V. E. Kuznetsova, V. E. Shershov, S. A. Surzhikov, V. A.Vasiliskov, S. A. Lapa, and A. V. Chudinov p. 1506  abstract

A Phenol-Free Method for the Robust Isolation of the Double-Stranded RNA Produced in the E. coli HT115 Strain

A. A. Ivanov, and T. S. Golubeva p. 1521  abstract

Synthesis, Bioactive Evaluation, and Preliminary Antibacterial Mechanism Study of Novel Ferulic Acid Derivatives

Song Bai, Miao Li, Rong Wu, Shouying Tang, Fang Wang, Lijun Chen, Xian Wei, Shuang Feng, Miaohe Zhang, and Suran Wan p. 1529  abstract

Olaparib Stimulates the Senescence of Ovarian Cancer Cells by Inhibiting SIRT1

Yanjun Wang, and Xi Liu p. 1547  abstract

Spiro(DHPM-isatin) Derivatives: Synthesis, Nematicidal Activity, and Computational Analysis

Jashandeep Kaur, Divya Utreja, N.K. Dhillon, Rajesh K. Pathak, and Harwinder Singh Buttar p. 1558  abstract

Synthesis of Tetraesters of Indolyl-3-acetic Acid with 24-Epibrassinosteroids and Their Influence on the Initial Growth of Wheat Plants

R. P. Litvinovskaya, N. E. Manzhаlesаva, А. P. Savachka, A. L. Sauchuk, and V. A. Khripach p. 1571  abstract

Integration of Software for Nanotomography-Based 3D Tissue Reconstruction

D. О. Solovyevа, О. Y. Popadinets, I. S. Kolpashnikov, A. V. Altunina, and V. A. Oleinikov p. 1579  abstract

Synthesis of Reactive Pegylated Indocyanine Dyes

V. E. Shershov, V. E. Kuznetsova, G. F. Shtylev, I. Yu. Shishkin, R. A. Miftakhov, V. I. Butvilovskaya, I. V. Grechishnikova, A. A. Stomakhin, O. A. Zasedateleva, and A. V. Chudinov p. 1586  abstract

Design, Synthesis, and Molecular Docking of Novel Fluorine-Containing 1,2,3-Triazole-tethered Pyrazole-Chalcone Derivatives as Antimicrobial Agents

M. S. Jangale, N. D. Bhoge, A. A. Pund, and B. K. Magare p. 1591  abstract

Design, Semi-Synthesis, and Antibacterial Activities of Triterpenoid-Hydrazone Conjugates

Pengju Yang, Yuting Liu, Yunyun Zhou, Zhiwen Zhou, and Yongzhong Li p. 1605  abstract

Cytotoxic Potential of Newly Synthesized 4-Aminoquinoline Hybrids on MDA-MB-231 Cells: Insights from Pharmacophore Modeling and Molecular Dynamics Simulation

A. A. Mattikopp, S. G. Alegaon, S. Gharge, S. D. Ranade, and R. S. Kavalapure p. 1624  abstract

Pharmacokinetic Characteristics of Ecdystene and Ursolic Acid in Plant Extracts After Oral Administration In Vivo

D. A. Kiseleva, S. V. An’kov, T. G. Tolstikova, A. A. Okhina, and A. D. Rogachev p. 1645  abstract

C-Terminal Domain of Bacillus cereus Hemolysin II is Capable of Forming Homo- and Hetero-Oligomeric Forms of the Toxin on the Membrane Surface

O. S. Vetrova, N. V. Rudenko, B. S. Mel’nik, A. P. Karatovskaya, A. V. Zamyatina, A. S. Nagel’, Zh. I. Andreeva-Kovalevskaya, A. V. Siunov, F. A. Brovko, and A. S. Solonin p. 1654  abstract

Molecular Species of Membrane Lipids of the Sea Anemone Exaiptasia diaphana and Its Symbionts

E. T. Bizikashvili, S. A. Kozlovskiy, E. V. Ermolenko, K. V. Efimova, and T. V. Sikorskaya p. 1663  abstract

Synthesis, Antimicrobial, Anti-Inflammatory, Antioxidant Activities, Molecular Docking, and Dynamic Simulations with Lanosterol 14α-Demethylase of Propionyl Glucopyranoside Derivatives

J. Ferdous, F. Ali, S. Saha, D. Palit, and S. M. A. Kawsar p. 1675  abstract

Synthesis of Fully Substituted 1,2,3-Triazoles via Organocatalytic [3+2] Cycloaddition: Incorporation of Pyrazole and Imidazole Scaffolds as Potent EGFR-Targeted Anticancer Agents

Sreenivas Tumu, A. Samba Shiva Rao, and Jagadeesh Kumar Ega p. 1700  abstract

Synthesis and Anti-Leukemia Activity of N-[1-(1-Adamantyl)ethyl]-3-hydroxylup-20(29)-en-28-amide

K. A. Barmina, I. I. Kulakov, V. S. Vlasenko, N. N. Novikova, E. A. Vishnevsky, and I. V. Kulakov p. 1715  abstract

Comparison of Alternative Piperidine Deblocking Agents in the Solid-Phase Synthesis of Ingramon and Methylin

M. V. Klimova, A. S. Molokoedov, M. V. Ovchinnikov, M. E. Palkeeva, U. S. Kozhokar, D. V. Avdeev, and M. V. Sidorova p. 1725  abstract

Chimeric Amides of Substituted Allyl- and Phenylcarboxylic Acids with Pharmacophoric Moieties of Aromatic and Heteroaromatic Rings as Potential Multitarget Protein Kinase Inhibitors: Design, Synthesis, Evaluation of Antitumor Activity, and In Silico Analysis

E. V. Koroleva, Yu. V. Siniutsich, A. L. Ermolinskaya, Zh. V. Ignatovich, Yu. V. Kornoushenko, O. V. Panibrat, Ya. M. Katok, and A. M. Andrianov p. 1734  abstract

Synthesis and Catalytic Optimization of Quinoline–Pyridine Hybrids as New Mannich Bases: An Effective Structural Motif in the Treatment of Tuberculosis

Heta B. Vasveliya, Jignesh H. Pandya, Hinaben K. Tilavat, and Amita J. Jivani p. 1752  abstract

Fabrication and Characterization of Piroxicam-Loaded Glycolated Chitosan-Stabilized Transdermal Patch

Sajid Raza, Muhammad Akhlaq, Aisha Siddiqua, Rukhshnda Habib, Khalid J. Alzahrani, Khalaf F. Alsharif, and Abul Kalam Azad p. 1762  abstract

Enzymatic Synthesis and Molecular Docking Studies of Substituted 5-Phenyl-1,2,4-triazole-3-thione Deoxyribosides

I. V. Fateev, S. A. Sasmakov, A. A. Ziyaev, Zh. M. Abdurakhmanov, T. T. Toshmurodov, S. A. Ikramov, N. A. Tosheva, V. D. Frolova, E. A. Zorina, E. A. Zayats, B. Z. Eletskaya, O. S. Smirnova, M. Ya. Berzina, A. O. Arnautova, Yu. A. Abramchik, M. A. Kostromina, A. L. Kayushin, K. V. Antonov, I. A. Prokhorenko, A. S. Paramonov, V. L. Аndronova, R. S. Esipov, Sh. S. Azimova, A. I. Miroshnikov, and I. D. Konstantinova p. 1780  abstract

Synthesis of New 1,4-Disubstituted 1,2,3-Triazole Hybrids: In Vitro Anti-Breast Cancer and Anti-EGFR Activity, and In Silico Molecular Docking Studies

Venu Kudapa, B. Saritha, and B. B. V. Sailaja p. 1789  abstract

Induction of Oxidative Hormesis by TiO2 Nanoparticles Enhances Antibacterial Activity of Lactobacillus acidophilus

A. V. Lokteva, E. V. Trushlis, O. V. Ivankova, and E. I. Koshel p. 1801  abstract

Synthesis of Carbazole-Fused Triazole Scaffolds: Evaluation of Anticancer Activity and Molecular Docking Studies

Kariyappa N. Ankali, B. Manjunatha, C. Kiran Yadav, Neelufar, Mallappa Shalavadi, and Nagaraja Naik p. 1813  abstract