Contents

Russian Journal of Bioorganic Chemistry

Vol. 52, No. 3, 2026

RESEARCH PAPER

Integrative Machine Learning Screening and Functional Validation of Autophagy-Related Genes in Osteoporosis

Jie Shi and Yongxian Wan p. 60  abstract

REVIEW PAPER

Mannich Bases in Antiviral Drug Development: Synthetic Approaches and Biological Potential

Vaishnavi D. Magar, Neha V. Bhilare, Vinayak S. Marulkar, Vasant Y. Lokhande, Harinath N. More, and Dileep Kumar p. 61  abstract

RESEARCH PAPER

Insights into Novel Tetrazole-Encompassing 1,2,3-Triazoles as Antimicrobial and Anti-TB Agents: Synthesis, ADME-Tox, and In Silico Molecular Docking

P. S. Reddy, T. Sekhar, P. Thriveni, A. T. Rao, T. Giridhar, V. A. Kumar, G. Srinivasulu, and P. V. V. N. Kishore p. 62  abstract

REVIEW PAPER

Modification-Driven Enhancement of Antimicrobial Activity in Cellulose-Based Materials: Trends and Applications (2021–2025)

Mohammed Sanad Alhussaini, AbdulRahman Abdulla Ibrahim Alyahya, and Abdullah Abdulrahman Al-Ghanayem p. 63  abstract

RESEARCH PAPER

Synthesis of Chromen–THP Hybrids as Dual Anticancer and Antioxidant Agents: In Silico and In Vitro Evaluation

Ansari Altamash Shakeel Ahmad, Mirza Shahid Baig, J. N. Sangshetti, and Yasar Qazi p. 64  abstract

Fused Imidazo[1,2-a]pyrimidines Containing 1,2,3-Triazoles and Isoxazoles: One-Pot Synthesis, Anticancer, and EGFR-Inhibitory Activities

Suresh S. Ardhapure, Nilesh B. Chavhan, Sainath L. Shinde, and Shivraj B. Sirsat p. 65  abstract

A MEMORIAL ARTICLE

Interactions with Alexander Arseniev at the ETH Zürich and Thereafter

Gerhard Wagner p. 66  abstract

RESEARCH PAPER

Influence of Mutant Alpha-Subunit Kv1.1(A261T) on the Properties of the Heterotetrameric Channel Kv1.1-Kv1.2

A. V. Efremenko, I. Dzhumaniiazova, D. V. Abramochkin, I. I. Shmatin, V. N. Korabeynikova, E. V. Kryukova, M. P. Kirpichnikov, A. V. Feofanov, and O. V. Nekrasova p. 67  abstract

Properties of LMNG/CHS Micelles

Konstantin Mineev and Harald Schwalbe p. 68  abstract

RESEARCH PAPER

NMR as a Video-(Game): Constructing Super-Resolution Cross-Peak Trajectories in Protein Spectroscopy

Chng Jing Hang, Yevheniia Kuznietsova, Mikhail Fillipov, and Konstantin Pervushin p. 69  abstract

Point Substitution N33D in the Light Chain of Neutralizing Antibody REGN10987 Increases the Fab Affinity to RBD of Omicron BA.1 SARS-CoV-2 Variant. In Silico Study

D. E. Nolde, M. V. Kocharovskaya, A. V. Popov, M. P. Kirpichnikov, E. N. Lyukmanova, and Z. O. Shenkarev p. 70  abstract

Structural Studies of the Eukaryotic Translation Initiation Factor eIF5A from Candida albicans by High-Resolution NMR Spectroscopy and X-Ray Crystallography

V. E. Gonyalin, P. V. Egorova, E. E. K. Agboigba, Sh. Z. Validov, A. D. Biktimirov, N. S. Garaeva, K. M. Boyko, V. V. Klochkov, A. V. Aganov, M. M. Yusupov, and K. S. Usachev p. 71  abstract

REVIEW PAPER

Ligand-Mediated Conformational Plasticity of the Pore Domain of TRPV6 Ion Channel

I. I. Veretenenko, V. V. Vantsev, Y. A. Trofimov, and R. G. Efremov p. 72  abstract

Backbone Structure-Conditioned Sequence Design Using Machine Learning-Based Approaches

I. Yu. Gushchin, A. S. Nikolaev, E. A. Kuznetsova, A. D. Bugrova, A. A. Afanasev, and A. A. Remeeva p. 73  abstract

REVIEW PAPER

Natural Neurotoxins in the Study of the Spatial Structure of Nicotinic Acetylcholine Receptors—the Main Milestones

I. E. Kasheverov, Yu. N. Utkin, and V. I. Tsetlin p. 74  abstract

Structural Biology of Zinc-Binding Proteins and Peptides

U. V. Bulgakova, K. I. Balagurov, A. Yu. Rudenko, K. N. Aysin, S. A. Goncharuk, S. S. Mariasina, P. G. Georgiev, E. V. Bocharov, and V. I. Polshakov p. 75  abstract

Structural Studies of Bacteriorhodopsin: What Do We Know and What Did We Miss?

M. A. Dubinnyi, S. S. Bukhdruker, V. I. Borshchevskiy, M. V. Goncharuk, I. S. Okhrimenko, E. V. Bocharov, and S. A. Goncharuk p. 76  abstract

ZHER2 Affibodies: A Versatile Platform for Diagnostics and Therapy of HER2Overexpressing Cancers

I. I. Tyuryaeva, E. I. Trosko, and D. A. Luzik p. 77  abstract

Lawsone-Derived Heterocycles: Synthetic Strategies, Structure–Activity Relationships, and Therapeutic Applications

J. P. Sonawane, V. S. Patil, V. K. Suryawanshi, S. S. Nandre, P. M. Raotale, and S. R. Patil p. 78  abstract

RESEARCH PAPER

From Green Synthesis to Biological Insight: A Multifaceted Study of Dibutyl (2-amino-3-cyano-4H-chromen-4-yl)phosphonates via DFT, ADMET, Docking, and In Vitro Assays

Sumithra Poreddy, Mohan Gundluru, Surendra Pothuraju, Santhisudha Sarva, Poojitha Bellala, Sunitha Gundubogula, Jyothibabu Sajila Arya, and Suresh Reddy Cirandur p. 79  abstract

Production and Structural-Functional Characterization of a Recombinant HIV-1 Env Trimer Based on the Consensus Sequence of the Most Prevalent Strains in the Russian Federation

I. A. Favorskaya, I. O. Ilyasov, I. A. Alekseeva, E. I. Ryabova, A. A. Antonova, D. A. Kleymenov, V. A. Gushchin, A. D. Burtseva, A. V. Moiseenko, T. S. Trifonova, V. O. Popov, N. N. Sluchanko, K. M. Boyko, D. V. Shcheblyakov, and D. Yu. Logunov p. 80  abstract

RESEARCH PAPER

Development of Mutant C120S Neuroglobin, Its Characteristics and Interaction with Cytochrome c

M. A. Semenova, R. G. Atrikhalov, O. M. Smirnova, V. V. Britikov, E. V. Britikova, A. A. Ignatova, Y. V. Bershatsky, A. P. Khodnenko, I. P. Oleynikov, S. A. Siletsky, T. V. Vygodina, E. V. Bocharov, M. P. Kirpichnikov, D. A. Dolgikh, and R. V. Chertkova p. 81  abstract

Bicelles as a Prospective Membrane Mimetic for NMR Structural Studies of Bacteriorhodopsin

M. V. Goncharuk, M. A. Dubinnyi, O. V. Nekrasova, A. S. Anurieva, P. K. Kuzmichev, V. V. Chupin, I. S. Okhrimenko, V. I. Borshchevskiy, E. V. Bocharov, A. S. Arseniev, and S. A. Goncharuk p. 82  abstract

Editorial Notes

Special Issue Dedicated to the 75th Anniversary of the Birth of an Outstanding Soviet/Russian Scientist, one of the Founders of Russian Structural Biology, Prof. Alexander Sergeevich Arseniev (1951–2025)

Kurt Wüthrich p. 83  abstract