Contents

Russian Journal of Bioorganic Chemistry

Vol. 51, No. 3, 2025

REVIEW PAPER

Naturally Occurring Alkaloids: Their Structural Elucidation and Biological Activity (2020–2024)

Fatima Choudry, Moonsa Haq, Shaneeza Tariq, Rimsha Kiran, Faiza Batool, Momna Haq, Ghulam Shabir, and Aamer Saeed p. 947  abstract

The Activity-Enhancing Effect of the 1,3-Dioxolane Ring in Biomedicine

Duha Adnan Hassan, and Yasser Fakri Mustafa p. 991  abstract

Smart Delivery Systems of Sorafenib Based on Biopolymers and Supramolecular Assemblies

I. M. Le-Deygen, A. A. Skuredina, Van Cuong Bui, Minh Bao Ngoc Tran, and Thi Lan Pham p. 1011  abstract

Role of Phospholipid Derivatives of Cyclodextrins in the Formation of Stable Lipid Nanoparticles for Drug Delivery

Е. D. Belitskaya, V. A. Oleinikov, and A. V. Zalygin p. 1022  abstract

RESEARCH PAPER

Design and Synthesis of Novel Imidazole-Bearing 1,2,3-Triazoles as Potent Anticancer Agents: Drug-Likeness, Pharmacophore, and Molecular Docking Exploration

B. V. Balaji, B. Hari Babu, G. Mahesh Kumar, B. Srinu, V. Pandu Ranga Rao, and R. Surya Chandra Rao p. 1034  abstract

Design, Synthesis, and Evaluation of Antitumor Activity of Novel Pyrimidine Derivatives Containing Acrylamide and a Cyano Group

Hongjing Chen, Dongling Gu, Jiahui Han, Zichen Yang, Shihao Wang, Lingling Chi, Fuqiang Yu, Hao Wang, Hongmin Liu, Yu Ke, and Qiurong Zhang p. 1054  abstract

A Novel Piperine Derivative, NOHJ, Exerts Antibreast Cancer Effects by Inhibiting MDM2

Xing Liu, Jingliang He, Wenhao Cheng, Xiaoshuo Wang, Meiqi Zhang, Sen Wang, Lu Chen, Siyi Zhang, Chongyun Zhou, Lili Zhou, Boyu Zhang, Dan Wang, Yizhuo Song, Xiujun Wang, and Jing Ji p. 1070  abstract

Mass Spectrometric Analysis of Post-Translational Modifications of Xenopus laevis Cytoskeletal Protein Zyxin

E. D. Ivanova, R. H. Ziganshin, E. A. Parshina, A. G. Zaraisky, and N. Y. Martynova p. 1083  abstract

Effect of Intrinsically Disordered Regions on the Expression of TIR Domains of the Toll-like Receptor in the Soluble Form

V. A. Lushpa, M. V. Goncharuk, A. S. Arseniev, K. S. Mineev, and S. A. Goncharuk p. 1092  abstract

Synthesis, Biological, and Computational Studies of Novel Isoxazolone-Coupled Azo Moieties and Their Photophysical Interactions

K. O. Karunasagar, Yadav D. Bodke, K. K. Vinay, and Y. Surendranaik p. 1099  abstract

Synthesis and Anticancer Activity of Diethyl (((5-(substituted phenyl)-1,3,4-thiadiazol-2-yl)amino)(quinolin-2-yl)methyl)phosphonate

Shailee V. Tiwari, Mahavir H. Ghante, Dattatraya N. Pansare, Nileema S. Gore, Rohini N. Shelke, and Shashikant V. Bhandari p. 1115  abstract

Combined Effects of Cytokine TRAIL-Based DR5-Specific Fusion Protein with Olaparib on Tumor Cell Lines with Different BRCA Mutation Status

A. V. Yagolovich, A. A. Isakova, E. V. Kukovyakina, D. A. Dolgikh, M. P. Kirpichnikov, and M. E. Gasparian p. 1128  abstract

Sequence Specificity of Dimeric Bisbenzimidazoles for DNA AT Sequences of Different Nucleotide Compositions, as Determined by Footprinting

D. S. Naberezhnov, А. F. Arutuynyan, А. D. Beniaminov, N. М. Smirnov, D. N. Kaluzhnyi, A. L. Zhuze, and O. Y. Susova p. 1137  abstract

Synthesis and Study of Cytotoxicity of 3β-Acetoxyurs-12-en-28-oyl-thiourea Derivatives

S. A. Popov, T. D. Borisova, E. E. Shults, M. K. Marenina, Yu. V. Meshkova, and T. G. Tolstikova p. 1147  abstract

Design, Synthesis, and Antimicrobial Study of Triad Hybrids of 1,2,3-Triazolo[4,5-b]pyridine: Click Chemistry and Azidation Using Hydrazine Hydrate

Heta B. Vasveliya, Jignesh H. Pandya, Hinaben K. Tilavat, Amita J. Jivani, and Tanzil A. Juneja p. 1161  abstract

Design, Synthesis, Molecular Docking, and Biological Evaluation of Novel 1,2,4-Oxadiazole-Based Derivatives as Inhibitors of Trypsin, ALDH2, and iNOS

Mohammed Salah Ayoup, Rabia E. Alashhab, Hamida Abdel-Hamid, Doaa A. Ghareeb, Aliaa Masoud, Amr Sonousi, Asmaa E. Kassab, and Mohamed N. Abd Al Moaty p. 1171  abstract

2-Fluorocordycepin: Chemoenzymatic Synthesis and Study of Anticancer Activities In Vitro

A. O. Arnautova, K. V. Antonov, E. A. Zorina, M. A. Simonova, A. S. Paramonov, O. S. Zhukova, M. V. Kiselevskiy, A. L. Kayushin, I. V. Fateev, E. V. Dorofeeva, B. Z. Eletskaya, M. Ya. Berzina, O. S. Smirnova, T. V. Egorova, R. S. Esipov, A. I. Miroshnikov, and I. D. Konstantinova p. 1189  abstract

Effect of Different Coatings on Immobilization of Biomolecules in Brush Polymer Cells

G. F. Shtylev, I. Yu. Shishkin, R. A. Miftakhov, S. A. Polyakov, V. E. Shershov, V. E. Kuznetsova, S. A. Surzhikov, V. I. Butvilovskaya, V. E. Barsky, V. A. Vasiliskov, O. A. Zasedateleva, and A. V. Chudinov p. 1206  abstract

TERT Promoter Mutation Analysis in Glioma Samples by Allele-Specific Biochip Hybridization

V. O. Varachev, I. O. Barinova, S. A. Surzhikov, O. Yu. Susova, A. A. Mitrofanov, I. V. Grechishnikova, A. S. Zasedatelev, A. V. Chudinov, and T. V. Nasedkina p. 1218  abstract

Synthesis, Spectral Characteristics, and Tumor Imaging of a Fluorescent Small-Molecule Probe Containing Selenium Indole Sulfonate

M. Liu, Z. Wang, and F. Jin p. 1224  abstract

Synthesis, Computational, and UV-Vis Absorption Studies of Novel Benzothiazole Azo Derivatives and Their Biological Potentials

K. K. Vinay, Yadav D. Bodke, Shivakumar Naik, and Udayakumar Dalimba p. 1233  abstract

Fluorescence Labeling of GC-Rich DNA Matrix with Different Nucleotide Derivatives for Hybridization Analysis on a Biological Microarray

I. O. Barinova, V. E. Shershov, V. O. Varachev, S. A. Surzhikov, I. V. Grechishnikova, O. A. Zasedateleva, T. V. Nasedkina, and A. V. Chudinov p. 1249  abstract

Comparison of DNA Analysis on Biochips with Brush Polymer Cells and Cross-Linked Polymer Cells

R. A. Miftakhov, G. F. Shtylev, I. Yu. Shishkin, V. E. Shershov, V. E. Kuznetsova, S. A. Surzhikov, V. A. Vasiliskov, O. A. Zasedateleva, A. Yu. Ikonnikova, T. V. Nasedkina, and A. V. Chudinov p. 1255  abstract

Synthesis of Novel N-Alkyl-3-mesityl-5-methyl-4,5-dihydro-isoxazole-5-carboxamide Molecules: In Vitro Antimicrobial, Antimalarial Evaluation, and In Silico Prediction Studies

Amit Chouhan, Sumit Kumar, Ajit Joshi, and Satyanarayana Battula p. 1262  abstract

Combined Effects of Senexin B and Antitumor Agents on Neuroblastoma and Glioblastoma Cell Lines

D. V. Mazur, S. S. Pogodaeva, O. A. Kuchur, O. O. Miletina, A. I. Rezekina, E. G. Petrosyan, D. A. Rudik, E. I. Ivanova, A. A. Shtil, and N. V. Antipova p. 1279  abstract

A Method for Increasing the Efficiency of Selection of Aptamers to Cellular Receptors

V. E. Kuznetsova, T. D. Lebedev, V. E. Shershov, G. F. Shtylev, I. Yu. Shishkin, R. A. Miftakhov, V. I. Butvilovskaya, I. V. Grechishnikova, O. A. Zasedateleva, and A. V. Chudinov p. 1287  abstract

Regulation of pou5f3 Family Pluripotency Gene Transcripts Stability by Ybx1 Ribonucleoprotein Complexes in Xenopus laevis Early Development

E. A. Parshina, A. G. Zaraisky, and N. Y. Martynova p. 1297  abstract

Environmentally Friendly Synthesis of Coumarin–Pyrazolo[1,5-a]pyrimidine Hybrids with Potent Antibacterial and Antibiofilm Activities

T. R. A. Sangma, L. B. Marpna, M. Rymbai, S. Kaping, V. V. Borah, and J. N. Vishwakarma p. 1306  abstract

Search for Possible Conjugation Sites of Electrophiles with Biomolecules by Molecular Modeling

D. A. Belinskaia, and E. I. Savelieva p. 1320  abstract

Evaluation of Natural Monoterpene Indole Alkaloids as Potent Fungicide Candidates

Zhuoyi Wang, Yanyan Chen, Hean Liu, Yueming Li, Mingjie Zhang, Yongyong Zhang, and Junwei Sun p. 1339  abstract

Assessment of Cytotoxic Potentials of Isoindole-Derived Compounds with Epoxy Alcohol Functionalities on Different Cancer Cell Lines and Molecular Docking Analysis

Egehan Yetişkin, Özlem Gündoğdu, Derya Mete, Nurhan H. Kishali, Yunus Kara, and Gülşah Şanlı-Mohamed p. 1346  abstract

Cytotoxic Potential of Newly Synthesized Quinoline–Bearing Dihydropyridine Hybrids on A549 Lung Cancer Cells

V. Kuthe, S. G. Alegaon, R. S. Kavalapure, S. Gharge, and S. D. Ranade p. 1365  abstract