Contents

Russian Journal of Bioorganic Chemistry

Vol. 51, No. 2, 2025

REVIEW PAPER

Pyran-Fused Analogues and Their Potential Applications

Sumit Kumar, Aditi Arora, Sandeep Kumar, Rajesh Kumar, Nihar Nalini Senapati, and Brajendra K. Singh p. 373  abstract

Comprehensive Review and Perspective on Fructose 1,6-Bisphosphatase Inhibitors for the Management of Type 2 Diabetes Mellitus

Sanjay D. Sawant, and Vasundhara N. Sawant p. 439  abstract

Instrumental Approaches to the Detection and Quantification of Surfactin

V. S. Trefilov, E. Yu. Lindin, M. V. Monakhova, O. V. Kisil, M. B. Viryasov, T. S. Oretskaya, and E. A. Kubareva p. 465  abstract

Gene Therapy Drugs Based on Synthetic Oligonucleotides

I. B. Kozlov, O. A. Gerasimov, O. Y. Domasheva, L. G. Bushina, L. A. Safonova, V. V. Makarov, and V. S. Yudin p. 491  abstract

Ursolic Acid: Sources, Synthesis, Properties, Modifications, Application

D. A. Kiseleva, S. V. An’kov, and T. G. Tolstikova p. 508  abstract

Application of Organic Fluorophores in the Development of Drug Delivery Systems Based on Synthetic and Natural Polymers

D. Y. Yuriev, S. V. Tkachenko, A. G. Polivanova, Y. K. Kryschenko, and M. S. Oshchepkov p. 533  abstract

Prospects for the Use of Antibody-Drug Conjugates in Cancer Therapy

A. O. Makarova, E. V. Svirshchevskaya, M. M. Titov, S. M. Deyev, and R. V. Kholodenko p. 556  abstract

RESEARCH PAPER

Synthesis and Biological Assessment of Novel Derivatives of 2-Oxo-tetrahydropyrimidine-5-carboxamides

S. Bhardwaj, H. Chopra, R. Agrawal, S. N. Mali, M. Akhlaquer Rahman, and A. Garg p. 574  abstract

Exploration of Indazole-Derived Oxadiazoles and Thiadiazoles as Potential Antimycobacterial Agents: Synthesis and In Silico Docking Analysis

V. S. R. Avuthu, A. B. Reddy, A. R. Basireddy, P. R. Patel, M. N. Ganivada, and P. V. V. N. Kishore p. 584  abstract

Targeting PI3K/AKT/mTOR Signaling with Novel Andrographolide Analogues Potentially Induces Apoptosis and Inhibits the Metastatic Ability of Human Breast Cancer Cells: Rational Design, Synthesis, and In Vitro Studies

Y. Vishwanadham, R. Madhuri, Shivaraj, D. Appaji, and W. Kavita p. 601  abstract

Design, Synthesis, Antioxidant, Antitubercular Activity, and In Silico Studies of Novel α-Amino Phosphonates of Vanillin, a Potent Bioactive Molecule

Mohammad Aasif, and J. A Banday p. 629  abstract

Exploring Synthesis, DFT Characterization, and Molecular Docking of β-Naphthol Derivatives: Investigating Dual Enzyme Inhibition and Antimicrobial Potential with ADMET Profiling

Janaki H. Chauhan, Bhavesh L. Dodiya, and Haresh K. Ram p. 642  abstract

Evaluation of Novel Spiro-1,4-dihydropyridine Derivatives as Potent Antimicrobial and Anticancer Agents

Richa Sharma, and Gajanand Sharma p. 673  abstract

Synthesis and Antimicrobial Screening of Some Thiazolidin-4-one Derivatives

M. Yadav, A. Kumar, Y. Murti, A. Jain, R. Dinkar, and S. N. Mali p. 683  abstract

Platinum Polyoxoniobate: Stability, Cytotoxicity, and Cellular Uptake

A. V. Yudkina, I. P. Vokhtantsev, D. A. Rychkov, V. V. Volchek, P. A. Abramov, M. N. Sokolov, and D. O. Zharkov p. 693  abstract

Single-Domain Nanobodies for Determination of Conformational Changes in Transferrin and Their Use in Fluorescent Polarization Immunoassay

L. I. Mukhametova, S. A. Eremin, I. V. Mikhura, O. S. Goryainova, A. M. Sachko, T. I. Ivanova, and S. V. Tillib p. 702  abstract

New Potential Fluorogenic Dyes with an Extended π-System Based on Arylidene-Azolones

S. A. Krasnova, A. V. Eshtukov-Shcheglov, A. Yu. Smirnov, Yu. A. Bogdanova, and M. S. Baranov p. 712  abstract

picoFAST: New Genetically Encoded Fluorescent Tag

N. S. Baleeva, M. V. Goncharuk, I. A. Ivanov, M. S. Baranov, and Yu. A. Bogdanova p. 721  abstract

Synthesis, Docking Study, and Structural Characterization of New Bioactive Thiazolidine-4-one Derivatives as Antibacterial and Antioxidant Agents

Zainab Y. Kadhim, and Hasanain Gomhor J. Alqaraghuli p. 729  abstract

Sunitinib Stimulates Cellular Senescence of Gastrointestinal Stromal Tumor Cells through Inhibition of SIRT1

Xuzheng Song, Hongbin Zhu, Jing Zhang, Dongxu Wang, Shiping Hu, and Bangmao Wang p. 743  abstract

Exploration of a Novel Indole/Pyrazole Scaffold as a Promising Dual α-Glucosidase and α-Amylase Inhibitor: an In Vitro, In Vivo and In Silico Approach Toward Antidiabetic Drug Design

Govinda Anjanayya, Ramesh Gani, Murigendra Hiremath, Apsara Kavital, Shrinivas Joshi, Karabasanagouda Timanagouda, Raifa Abdul Aziz, Shamprasad Varija Raghu, and and Basavarajaiah Suliphuldevara Mathada p. 755  abstract

The Impact of Zyxin Modifications on Its Intracellular Distribution in the Xenopus Laevis Embryo Model

E. A. Parshina, E. D. Ivanova, A. G. Zaraisky, and N. Y. Martynova p. 772  abstract

A Monoclonal Antibody Against the Oligomeric Form of the Large C-Terminal Fragment (Met225–Ile412) of Bacillus cereus Hemolysin II is Capable of Strain-Specific Inhibition of the Hemolytic Activity

O. S. Vetrova, N. V. Rudenko, A. V. Zamyatina, A. S. Nagel, Zh. I. Andreeva-Kovalevskaya, A. V. Siunov, F. A. Brovko, A. S. Solonin, and A. P. Karatovskaya p. 784  abstract

Antituberculosis Action of the Synthetic Peptide LKEKK

E. V. Navolotskaya, D. V. Zinchenko, A. A. Kolobov, Yu. A. Zolotarev, and A. N. Murashev p. 793  abstract

Synthesis and Medicinal Impacts of Novel 3,3′-Bihalocoumarins and Their Precursors, 7-Halocoumarin-3-acetic Acids

Yasser Fakri Mustafa, Marwa Mohammed Alshaher, Duha Adnan Hassan, and Ayman Faris Faisal p. 802  abstract

Exploration of Some Thieno[2,3-b]pyridines, Thieno[3,2-d]pyrimidinones, and Thieno[3,2-d][1,2,3]triazinones as Insecticidal Agents Against Aonidiella aurantii

Etify A. Bakhite, Mohamed A. Gad, Esraa Khamies, Felwa A. Thagfan, Rania Ali El Hadi Mohamed, and Moustafa M. S. Bakry p. 816  abstract

Design, Synthesis, and Antimicrobial Evaluation of Novel 5-Chloropyridine Oxalamide Conjugates as In Vitro and In Silico Inhibitors of E. coli DNA Gyrase and C. albicans Sterol 14α-Demethylase (CYP51)

Dilip C. Kanjariya, Hem N. Naik, Meet J. Sherashiya, Yogesh T. Naliapara, Dhanji Rajani, and Smita Jauhari p. 827  abstract

Synthesis and Properties of Phosphoryl Guanidine Oligonucleotides Containing 2′,4′-Locked Nucleotides

E. S. Dyudeeva, P. K. Lyapin, and E. V. Dmitrienko p. 850  abstract

Enzymatic Synthesis of Biologically Active 5-Substituted Analogues of 2ʹ-Deoxyuridine by Lactobacillus leichmannii Nucleoside Deoxyribosyltransferase Type II

C. S. Alexeev, A. M. Sergievskaia, D. A. Platov, and M. S. Drenichev p. 860  abstract

Design, Synthesis, and Antitumor Activity Evaluation of Novel 2,4,7-Trisubstituted Quinazoline Derivatives Containing an Aminomethyl Piperidine Moiety

Han Jiahui, Wang Shihao, Chen Hongjing, Gu Dongling, Yang Zichen, Wang Hao, Yu Fuqiang, Chi Lingling, Ke Yu, Liu Hongmin, and Zhang Qiurong p. 869  abstract

Analogue-Based Design, Synthesis, and Antimicrobial Study of Aryl and Heteroaryl Sulfonamides as Multi-Targeted Antimicrobial Compounds

Prangya Parimita Panda, Manaswini Patra, Bairagi Charan Mallick, and Abhijit Saha p. 886  abstract

Investigation of Quinoxaline-1,2,3-triazole Derivatives for Targeting SARS-CoV-2 via RBD Binding and PLpro Inhibition

Amr Negm, Ahmad R. Rabee, Hamida Abdel-Hamid, Samah A. Nasr, Doaa A. Ghareeb, Rabab S. Ibrahim, Mohammed B. Hawsawi, Ahmed M. Abdelmoneim, Magda M. F. Ismail, and Mohammed Salah Ayoup p. 901  abstract

Design, Synthesis, and Anti-Alzheimer Activity of 2,5-Disubstituted 1,3,4-Thiadiazole: Kinetic Studies, Molecular Docking, and MD Simulations

M. L. Sujatha, Prabhu Jalihal, Manjunatha S. Katagi, Durgesh Paresh Bidye, Sheshagiri R. Dixit, and B. P. Nandeshwarappa p. 912  abstract

Ultrasound-Assisted Synthesis of Polyfunctionalized Pyridine Derivatives Catalyzed by Silica-Supported Perchloric Acid: In Vitro Anticancer Studies and Molecular Docking

N. Hussain Basha, T. Jagadish, P. Karthikeyan, Krishnakumar Balu, Mani Durai, Mohd Afzal, Young-Ho Ahn, M. Pasupathi, and K. Venkatesan p. 932  abstract