Contents

Molecular Biology

Vol. 59, No. 5, 2025

REVIEWS

Analogs and Conjugates of Natural Proline-Arginine-Rich Antimicrobial Peptides: Application Potential

F. R. Bazhutov, Z. Z. Khairullina, A. G. Tereshchenkov, and N. V. Sumbatyan p. 627  abstract

Zinc-Dependent Histone Deacetylase (HDAC) Inhibitors: Therapeutic Potential, Pharmacophore Structure, and Methods for Testing Deacylase Activity

A. S. Zemskaya, S. N. Kochetkov, and M. V. Kozlov p. 668  abstract

Genetic Aspects of the Application of Tissue-Engineered Constructs in Regenerative Therapy in Cardiology: An Analytical Review

I. S. Kiselev, N. A. Matveeva, I. B. Beloglazova, O. G. Kulakova, and O. O. Favorova p. 691  abstract

GENOMICS: TRANSCRIPTOMICS

A Localized GTEx Database and Its Potential Applications in Biomedical Research

G. A. Churakov, M. D. Belyakov, T. S. Sall, and S. V. Orlov p. 707  abstract

CELL MOLECULAR BIOLOGY

IFNγ Upregulating miR-1291 Promotes Cell Proliferation and Enhances Phosphorylation of the JAK/STAT Signaling Pathway by Targeting SOCS3 in HepG2 Cells

X. Q. Li, F. F. Peng, Y. T. Xu, L. R. Chen, K. Lan, F. N. Hu, Y. Long, S. H. Wang, D. X. Lu, X. Y. Huang, Z. J. Huang, L. L. Chen, X. Q. Qin, and M. C. Qin p. 729  abstract

Spatial Organization of Chromatin of ZEB1 Gene Promoter Region in Pancreatic Ductal Adenocarcinoma Cells

M. V. Zinovyeva and L. G. Nikolaev p. 748  abstract

STM2457 is Therapeutic for Idiopathic Pulmonary Fibrosis by Inhibiting the METTL3-CTGF Signaling Axis

X. Sun and J. He p. 763  abstract

OLR1 Knockdown Mitigates Traumatic-Hemorrhagic Shock-Induced Liver Injury by Inhibiting the TLR4/MYD88 Pathway and NLRP3 Inflammasome Activation

H. Yao, N. Wang, Z. Huan, J. Han, M. Zhao, and X. Ge p. 772  abstract

Chrysin Boosts the Cell Death and Anticancer Actions of Doxorubicin by Stimulating the TRPM2 Channel in Glioblastoma Cells

Y. Yazğan and K. Yıldızhan p. 784  abstract

MOLECULAR CELL BIOLOGY

Amidothiazole Derivatives of (+)-Usnic Acid Effectively Inhibit TDP1 and Sensitize Tumor Cells to the Effects of Topotecan

A. A. Chepanova, A. L. Zakharenko, N. S. Dyrkheeva, I. A. Chernyshova, A. S. Filimonov, O. A. Luzina, M. S. Kupryushkin, S. A. Zhukov, A. V. Tsukanov, N. F. Salakhutdinov, and O. I. Lavrik p. 795  abstract

Coordinated Expression and Methylation of microRNAs: Role in Common Biological Processes and Signaling Pathways in Breast Cancer

E. A. Filippova, I. V. Pronina, V. I. Loginov, T. P. Kazubskaya, and E. A. Braga p. 805  abstract

STRUCTURAL-FUNCTIONAL ANALYSIS OF BIOPOLYMERS AND THEIR COMPLEXES

Substrate Specificity of E. coli Purine Nucleoside Phosphorylase in Phosphorolysis of Purine Ribonucleosides Containing a Cyclic Terpene Fragment

A. A. Kozlova, V. E. Oslovsky, M. A. Varga, C. S. Alexeev, and M. S. Drenichev p. 817  abstract

BIOINFORMATICS

GeneLens: A Python Package Implementing Monte Carlo Machine Learning and Network Analysis Methods for Biomarker Discovery and Gene Functional Annotation

G. J. Osmak and M. V. Pisklova p. 827  abstract

PROTEOMICS

Prediction of New Nε-Acetylation Sites in the Human Proteome Based on Molecular Multilevel Neighborhoods of Atom Descriptors

N. V. Lebedev, D. A. Filimonov, V. V. Poroikov, and A. A. Lagunin p. 836  abstract