Vol. 57, No. 2, 2023

Molecular Biology

Bioinformatics and Systems Computer Biology

Molecular Mechanisms to Optimize Gene Translation Elongation Differ Significantly in Bacteria with and without Nonribosomal Peptides

A. I. Klimenko, S. A. Lashin, N. A. Kolchanov, D. A. Afonnikov and Yu. G. Matushkin p. 155 abstract

Primary and Secondary micro-RNA Modulation the Extrinsic Pathway of Apoptosis in Hepatocellular Carcinoma

T. M. Khlebodarova, P. S. Demenkov, T. V. Ivanisenko, E. A. Antropova, I. N. Lavrik and V. A. Ivanisenko p. 165 abstract

Geometric Approach to Phylogeographic Analysis Molecular Genetic Sequences: Principal Components and Dendrograms

V. M. Efimov, K. V. Efimov and V. Yu. Kovaleva p. 176 abstract

Bioinformatics, Bioengineering, and Biotechnology

Comparative Analysis of Family A DNA-Polymerases as a Searching Tool for Enzymes with New Properties

A. A. Bulygin, A. A. Kuznetsova, O. S. Fedorova and N. A. Kuznetsov p. 182 abstract

Genotype-Specific Features of Cold-Induced Sweetening Process Regulation in Potato Varieties Nikulinsky, Symfonia, and Nevsky

A. A. Egorova, I. A. Saboiev, N. E. Kostina, D. D. Kuvaeva, A. B. Shcherban, S. M. Ibragimova, E. A. Salina and A. V. Kochetov p. 193 abstract

Modern Approaches to Protein Engineering to Create Enzymes with New Catalytic Properties

T. E. Tyugashev, O. S. Fedorova and N. A. Kuznetsov p. 204 abstract

Systemic Pharmacology and Creation of New Medical Technologies

Effect of Usnic Acid-Derived Tyrosyl-DNA Phosphodiesterase 1 Inhibitor Used as Monotherapy or in Combination with Olaparib on Transplanted Tumors In Vivo

T. E. Kornienko, A. L. Zakharenko, E. S. Ilina, A. A. Chepanova, O. D. Zakharova, N. S. Dyrkheeva, N. A. Popova, V. P. Nikolin, A. S. Filimonov, O. A. Luzina, N. F. Salakhutdinov and O. I. Lavrik p. 214 abstract

On Immunological Studies at Sirius University of Science and Technology

I. V. Astrakhantseva, V. G. Krut’, S. A. Chuvpilo, D. V. Shevyrev, A. N. Shumeev, S. A. Rybtsov and S. A. Nedospasov p. 225 abstract

Abnormal mTOR Signaling Pathway Activity in Autism Spectrum Disorders: Prospects of Mechanism-Based Therapy

E. A. Trifonova, A. A. Kotliarova and A. V. Kochetov p. 235 abstract

Cell Molecular Biology: From DNA Repair to Metabolomics

Poly(ADP-Ribose) Polymerases 1 and 2: Classical Functions and Interaction with New Histone Poly(ADP-Ribosyl)ation Factor HPF1

T. A. Kurgina and O. I. Lavrik p. 245 abstract

Mechanisms of the Specificity of the CRISPR/Cas9 System in Genome Editing

L. M. Kulishova, I. P. Vokhtantsev, D. V. Kim and D. O. Zharkov p. 258 abstract

Influence of the Poly(ADP-Ribose) Polymerase 1 Level on the Status of Base Excision Repair in Human Cells

E. S. Ilina, A. S. Kochetkova, E. A. Belousova, M. M. Kutuzov, O. I. Lavrik and S. N. Khodyreva p. 272 abstract

Alterations in the Level of mRNA of TPH1, TPH2 Genes, Tryptophan Hydroxylase Activity and Serotonin Metabolism in Mouse Brain Five Days after Lipopolysaccharide Administration

D. V. Sherbakov, A. B. Arefieva, P. D. Komleva, A. E. Iz’urov, N. V. Khotskin, D. V. Bazovkina and A. V. Kulikov p. 284 abstract

Potential of Interferon Lambda as an Inhibitor of SARS-CoV-2

L. A. Oleinik, P. G. Madonov and M. B. Pykhtina p. 291 abstract

DNA Probes for Analysis of the Activity of Key Enzymes of the Base Excision DNA Repair Pathway in Human Cells

I. V. Alekseeva, A. A. Kuznetsova, O. A. Kladova, V. O. Shender, P. V. Schneider, O. S. Fedorova and N. A. Kuznetsov p. 299 abstract

Structural-Functional Analysis of Biopolymers and Their Complexes

Factors Affecting the Stability of the Trimer of 2'-Deoxyuridine 5'-Triphosphate Nucleotide Hydrolase from Escherichia coli

A. V. Yudkina, E. A. Kovalenko, A. V. Endutkin, E. P. Panferova, A. A. Kirilenko, A. A. Kokhanenko and D. O. Zharkov p. 312 abstract

New Zwitter-Ionic Oligonucleotides: Preparation and Complementary Binding

D. E. Patrushev, E. A. Burakova, S. N. Bizyaev, A. A. Fokina and D. A. Stetsenko p. 320 abstract

Evolutionary, Population, and Medical Genomics, Transcriptomics

Increased Frequencies of the ‒174G and ‒572C IL6 Alleles in Populations of Indigenous Peoples of Siberia Compared to Russians

L. E. Tabikhanova, L. P. Osipova, T. V. Churkina, S. S. Kovalev, M. L. Filipenko and E. N. Voronina p. 329 abstract

Profiling of Targeted miRNAs (8-nt) for the Genes Involved in Type 2 Diabetes Mellitus and Cardiac Hypertrophy

K. Hussain, A. Ishtiaq, I. Mushtaq and I. Murtaza p. 338 abstract

Genes Associated with Increased Stress Sensitivity in Hypertensive ISIAH Rats

L. A. Fedoseeva, S. E. Smolenskaya, A. L. Markel and O. E. Redina p. 346 abstract

Changes in Expression of Genes Associated with Calcium Processes in the Hippocampus in Mice Exposed to Chronic Social Stress

M. B. Pavlova, D. A. Smagin, N. N. Kudryavtseva and N. A. Dyuzhikova p. 356 abstract

The P-Element Has Not Significant Effect on the Drosophila simulans Viability

L. P. Zakharenko, D. V. Petrovskii and R. A. Bykov p. 366 abstract