Controlled Synthesis of Polymer Matrices Based on N-Vinyl Succinimide and N-Vinylpyrrolidone for Immobilization of Low Molecular Weight Active Pharmaceutical Ingredients

Abstract— The molecular weight characteristics and physicochemical properties of poly-N-vinyl succinimide synthesized under conditions of reversible addition–fragmentation chain transfer mechanism at different concentrations of the chain transfer agent, dibenzyl trithiocarbonate, were determined. The possibilities of N-vinyl succinimide and N-vinylpyrrolidone copolymers with specified molecular weight characteristics of block and gradient microstructures synthesis are considered A method is shown for producing water-soluble polymer matrices based on copolymers of N-vinylsuccinamic acid and N-vinylpyrrolidone, intended for immobilization of low molecular weight compounds exhibiting bioactive properties. Oil-soluble rimantadine and trimecaine were converted into a water-soluble form by interaction with the produced copolymer.