Specific Transport Properties of Medicinal Chitosan Films

E. I. Kulish^a, A. S. Shurshina^a, and S. V. Kolesov^b

^a Bashkir State University, ul. Zaki Validi 32, Ufa, 450074 Bashkortostan, Russia

^b Institute of Organic Chemistry, Ufa Research Center, Russian Academy of Sciences,
pr. Oktyabrya 71, Ufa, 450054 Bashkortostan, Russia

e-mail: alenakulish@rambler.ru

Received July 10, 2013;
Revised Manuscript Received October 24, 2013

Abstract—Processes of water-vapor sorption by medicinal chitosan films and the kinetics of release of antibi-
otics of the cephalosporin series from these films have been studied. It has been found that the structural
changes in the polymer matrix that are related particularly to its chemical modification via the interaction with
drugs are the most probable cause of the deviation of the mass-transfer mechanism from the classical Fick’s
mechanism.

DOI: 10.1134/S0965545X14030080

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