Study of Antimicrobial and Hemolytic Activities
of Silver Nanoparticles Prepared by Chemical Reduction

O. Yu. Golubeva^a, *, O. V. Shamova^b, D. S. Orlov^b, T. Yu. Pazina^b, A. S. Boldina^a, and V. N.
Kokryakov^b

^aGrebenshchikov Institute of Silicate Chemistry, Russian Academy of Sciences,
nab. Admirala Makarova 2, St. Petersburg, 199034 Russia

* e-mail: olga_isc@mail.ru

^bInstitute of Experimental Medicine, North-Western Branch, Russian Academy of Medical Sciences,
ul. Akademika Pavlova 12, St. Petersburg, 197376 Russia

Received March 9, 2010

Abstract—Hydrosols that contain silver nanoparticles with average particle sizes of 10–15 and 20–25 nm have
been synthesized using chemical reduction. The antimicrobial activity with respect to the Gram-negative bacteria
Escherichia coli ML35p and Pseudomonas aeruginosa ATCC 27 853, the antibiotic-resistant clinical isolate of
Pseudomonas aeruginosa, and the Gram-positive bacteria Staphylococci aureus SG511 and Listeria monocytoge-
nes EGD, as well as the hemolytic activity of the synthesized samples, has been investigated. The results obtained
have shown that the use of the samples under investigation for the development of new bactericides holds promise.

Key words: silver, nanoparticles, hydrosols, chemical reduction, tannin, sodium boron hydride, antimicrobial
activity, hemolytic activity

DOI: 10.1134/S1087659610050135

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