in an Enzyme
Substrate Complex Reversible? The Experience of the Fractionation of Isotopes
in Enzymatic Reactions
A. L. Buchachenko
Semenov Institute of Chemical Physics, Russian Academy of Sciences, ul. Kosygina 4, Moscow, 117977 Russia
Received December 20, 2002
Abstract—An irreversible chemical transformation in an enzyme–substrate complex is accompanied by iso-
tope fractionation that only simulates thermodynamic equilibrium but is determined by the kinetic isotope
effect. The conclusion is drawn that elementary chemical transformations in enzyme–substrate complexes are
irreversible.
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