E. S. Chukhrai*, O. M. Poltorak*, L. F. Atyaksheva*, V. V. Voznesenskaya*, and C. J. Wysocki**
* Faculty of Chemistry, Moscow State University, Moscow, 119899 Russia
** Monnell Chemical Senses Center, 3500 Market str., Philadelphia, PA 19104 USA
Received May 20, 1996
Abstract—Alkaline phosphatase immobilized on the outer membranes of the olfactory epithelium (OE)
extracted from the nasal cavity of purebred mice sensitive (CBA) and insensitive (NZB) to the androstenone
odorant exhibits different kinetic and catalytic properties. Androstenone binding with olfactory receptors acti-
vates (for CBA) or inhibits (for NZB) alkaline phosphatase. The phosphatase of the androstenone receptors
becomes active only after the androstenone–receptor complex has formed. The existence of the latent and signal
states of the olfactory receptors was suggested.
Pleiades Publishing home page | journal home page | top
If you have any problems with this server, contact webmaster.