Hemolysis Induced by a Preliminarily
Photooxidation of Psoralen

N. N. Zhuravel’*, I. V. Belichenko**, E. M. Khalilov*, A. Ya. Potapenko**, and W. Adam***

* Research Institute of Physicochemical Medicine, Moscow
** Russian State Medical University, ul. Ostrovityanova 1, Moscow, 117861 Russia
*** Institute of Organic Chemistry, Wurzburg, Germany

Received November 8, 1995

Abstract—An influence of the concentration of psoralen on hemolysis induced by the preliminarily photoox-
idized psoralen was studied. It was shown that the yield of photoproducts, hemolysins, increased with psoralen
concentration if the initial concentrations of irradiated psoralen were small (less than 20 mM); a further increase
in psoralen concentration resulted in a decline in hemolysin yield. At high psoralen concentrations (higher than
20 mM), the triplet excited states of psoralen were suggested to be quenched with the unexcited psoralen mol-
ecules, and hemolysin formation was prevented.

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