Antibiotic Drug Solubility and Thermodynamics Profile in Binary (1,4-Dioxane, Acetonitrile, and Water) Solvents at Different Temperatures (T = 298.15–318.15 K)
Ravibhai Bholaa, Rizwan Ghumarab, Chirag Patelc, Keyur Bhatta,*, and Hasit Vaghania,**
a Department of Chemistry, Faculty of Science, Ganpat University, Mehsana, India
b Department of Chemistry, Tolani College of Arts and Science, Adipur, India
c Department of Chemistry, Krantiguru Shyamji Krishna Verma Kachchh University, Bhuj, India
Correspondence to: *e-mail: kdb01@ganpatuniversity.ac.in
Correspondence to: **e-mail: hvv01@ganpatuniversity.ac.in
Received 20 December, 2022
Abstract—Cefpodoxime proxetil (CP) solubility in binary solvent mixtures (1,4-dioxane + water and acetonitrile + water) was tested using the gravimetric method at temperature between 298.15 to 318.15 K and under normal atmospheric pressure. The experimental mole fraction solubility of CP was increased with increasing temperature as well as with the proportion of co-solvent in all systems. Then Apelblat, Buchowski-Ksiazczak, Van’t Hoff, $CNIBS{\text{/}}R{\kern 1pt} - {\kern 1pt} K$ and the modified Jouyban-Acree models were used for the prediction of the theoretical mole fraction solubility of CP. The experimental and theoretical mole fraction solubility were found to be good in this arrangement. Additionally, thermodynamics modeling of CP was carried out by using Van’t Hoff’s equation. The data on the solubility and thermodynamics would be useful in the production, isolation, separation, and crystallization of CP.
Keywords: solubility, antibiotic drug, Van’t Hoff model, solution thermodynamics analysis
DOI: 10.1134/S0036024423130186