Pyrrole Analogues of Phencyclidine Decrease Food
and Water Consumption in Mice¹

J. Solati^a,2, A. Ahmadi^b, S. Pakzad^b, and A. A. Salari^c

^aDepartment of Biology, Islamic Azad University, Karaj Branch, Karaj, Iran

^bDepartment of Chemistry, Faculty of Science, Islamic Azad University, Karaj Branch, Karaj, Iran

^cIslamic Azard University, Tehran North Branch, Department of Biology, Tehran, Iran

Received April 10, 2011

Abstract—Various studies have shown that Phencyclidine (1-[1-phenylcyciohexyl] piperidine, PCP, I) and many
of its analogues demonstrate pharmacological effects. In this paper effects of some new pyrrole derivatives of, (1-
[1-phenylcyclohexyl] pyrrole I, II, and 1-[1-[4-methylphenyl][cyclohexyl]]-pyrrole III) on food and water intake
in mice were investigated. Animals were deprived for 24 h before initial of each test for food and water intake eval-
uation. PCP and its derivatives were injected intraperitoneally (i.p.) and then in 1–12 hour and 30–180 min post-
injection, the treated groups were measured for food and water intake, respectfully. The results obtained from the
present study show that the pyrrole derivatives of PCP (II and III), decrease food and water intake in the deprived
mice dramatically in comparison with the vehicle treated control groups. Our results suggest that the pyrrole deriv-
atives of phencyclidine (II and III) affect those parts of central nervous systems that are involved in feeding behav-
ior.

Keywords: phencyclidine, pyrrole derivatives, food intake, water intake, mice

DOI: 10.1134/S1819712411040167

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