Disturbance of HSP70 Chaperone Activity
Is a Possible Mechanism of Mitochondrial Dysfunction

I. F. Belenichev, Yu. M. Kolesnik, S. V. Pavlov, E. P. Sokolik¹, and N. V. Bukhtiyarova

Zaporozhskii State Medical University, Zaporozh’e, Ukraine

Received March 26, 2011

Abstract—We studied the involvement of HSP70 and Hif1b genes in the development of pathological changes
in the brains of experimental animals during ischemia. We found neuro- and mitoprotective characteristics of
heat shock protein HSP70 and Hif1b in vitro and under cerebral ischemia due to stabilization of molecules dam-
aged by oxidation, inhibition of nitrosative and oxidative stress and mitoprotective action directed to ameliora-
tion of mitochondrial dysfuction. The protective role of these proteins provides a new direction for the devel-
opment of novel neuroprotective drugs that protect or modulate the genes that encode these proteins.

Keywords: mitochondrial dysfunction, heat shock proteins, chaperones, ischemia

DOI: 10.1134/S1819712411040040

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