L. H. Tadevosyan1, L. N. Arakelyan, M. A. Simonyan, G. A. Kevorkian, and A. A. Galoyan
Buniatian Institute of Biochemistry, National Academy of Sciences, Republic of Armenia
Received March 28, 2011
Abstract—Doxorubicin (DR) is a potential antineoplastic drug that is used for therapy of different types of
malignant tumors (leukemia, lymphoma, mammary tumor, lung, ovarian, pancreatic tumor etc.). However, the
long-term use of DR leads to irreversible cardiomyopathy and nephropathy due to DR-induced formation of
free oxygen radicals that disturb the functionality of the mitochondria, membranes, and nuclei of cells. The
mechanisms of DR-induced cardiotoxicity and nephrotoxicity associated with changes in the activity of anti-
oxidant metalloproteins (Cu, Zn-SOD, Mn-SOD, and catalase) and prooxidant metalloproteins (acidic isoforms
of cytochrome (cyt) b558 and cyt C) in heart and kidney cells are not clear. Here we tried to evaluate these bio-
chemical factors.
Keywords: metalloproteins, activity, doxorubicin, galarmin
DOI: 10.1134/S1819712411030123
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