Investigation of the Antioxidant Characteristics of a New
Tryptamine Derivative of Securinine and its Influence on Seizure
Activity
in the Brain in Experimental Epilepsy

M. E. Neganova^a,1, V. A. Blik^b, S. G. Klochkov^a, N. E. Chepurnova^b, and E. F. Shevtsova^a

^aInstitute of Physiologically Active Compounds, Russian Academy of Sciences, Chernogolovka, Russia

^bMoscow State University, Moscow, Russia

Received December 14, 2010

Abstract—We studied the mechanisms of the antioxidant activity of a tryptamine derivative of securinine
(TDS) and its influence on the dynamics of seizure activity in various models of experimental epilepsy. We
found that the new TDS, which possesses an antioxidant and a chelating effect, has anticonvulsant action in lith-
ium–pilocarpine-induced epilepsy and may be of interest as a potential scaffold for the development of new
neuroprotective anticonvulsant drugs.

Keywords: derivative of securinine, antioxidants, neuroprotectors, lipid peroxidation, models of epilepsy

DOI: 10.1134/S1819712411030056

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