M. M. Gabaeva, L. A. Nazarova1, E. V. Baziyan, A. A. Yakovleva, T. I. Oparina,
V. M. Prokopenko, V. L. Pastushenkov, N. N. Konstantinova, and N. G. Pavlova
Ott Research Institute of Obsterics and Gynecology, North-Western Division,
Russian Academy of Medical Sciences, St. Petersburg, Russia
Received April 14, 2011
Abstract—We studied the effects of a derivative of indole morphine (Trisan) during induction of labor on the
activity of enzymes of antioxidant defense in the brains of fetuses that developed under normal (intact) and dis-
turbed (experimental) placental blood circulation. We show that Trisan has antihypoxic and moderate antioxi-
dant characteristics and decreased intranatal oxidative stress in the CNS of intact and experimental fetuses.
Keywords: fetal hypoxia, brain, placental insufficiency, antioxidant system
DOI: 10.1134/S1819712411030020
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