S. A. Stroeva,b, E. I. Tyul’kovab,1, L. A. Vataevac, M. O. Samoilovb, and M. T. Pelto-Huikkoa
aDepartment of Developmental Biology, University of Tampere Medical School, Tampere, Finland
bLaboratory of the Regulation of Functions of Neurons of the Brain, Pavlov Institute of Physiology,
Russian Academy of Sciences, St. Petersburg, Russia
cLaboratory of Ontogeny of the Nervous System, Pavlov Institute of Physiology, Russian Academy of Sciences,
St. Petersburg, Russia
Received February 24, 2011
Abstract—We studied the expression of the antioxidant protein thioredoxin-1 in the hippocampus of rat pups that
were subjected to hypoxia at prenatal days 14–16, at the 3rd and 14th days after their birth, and at 80–90 days when
the pups became mature. In spite of the specific features of certain hippocampal regions and the presence of
exceptions related to them, 3 days after birth we observed a general trend to a decrease in thioredoxin-1 expression
in rats subjected to hypoxia, as compared to the control animals of the same age. Then, thioredoxin-1 expression
was substantially increased on the 14th day of postnatal life. In adult rats, thioredoxin-1 expression decreased
again. These changes were very prominent in the CA1 field of the hippocampus. A decrease in the activity of
the physiological antioxidant system is an important index of cell-membrane homeostasis, whose impairment
under hypoxic conditions can result in the development of neurodegenerative diseases.
Keywords: prenatal hypoxia, hippocampus, thioredoxin-1
DOI: 10.1134/S1819712411030111
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