Stress: Effects on Interleukin-1
and Erythropoietin
A. K. Piskunov1, A. A. Yakovlev, M. Yu. Stepanichev, M. V. Onufriev, and N. V. Gulyaeva
Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia
Received October 1, 2010
Abstract—The selective vulnerability of the hippocampus to damaging extreme influences, ischemia, hypoxia,
and metabolic stress is well known. However, the question of the selective vulnerability of the hippocampus to
acute interoceptive stress remains to be investigated. Here, we studied the time course of the neuroinflammatory
response to systemic administration of bacterial LPS at a high dose. We examined the level of proinflammatory
cytokine interleukin-1
and the expression of the cytoprotective protein erythropoietin and correlations between
these indices. We found that interoceptive stress induced a rapid inflammatory response in the nervous tissue,
which may be considered as an adaptive response. The neuroinflammation declined in the neocortex but increased
in the hippocampus. This effect may be considered as the deadaptation of this structure at this stage of the inflam-
matory response.
Keywords: lipopolysaccharide, brain, hippocampus, neuroinflammation, adaptation, interleukin-1, erythropoietin
DOI: 10.1134/S1819712411020061
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