Current Approaches and Future Directions of Gene Therapy
in Alzheimers Disease

M. Yu. Stepanichev¹

Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia

Received September 21, 2010

Abstract—We review the results of preclinical studies and clinical trials of gene therapy for the treatment of
Alzheimer’s disease. The possible application of gene-therapy approaches is discussed from the point of view
of the pathogenesis of this disease. The problems and future directions of the clinical use of gene therapy for
the treatment of Alzheimer’s disease are discussed.

Keywords: Alzheimer’s disease, neurodegeneration, gene therapy, viral vector, nerve growth factor

DOI: 10.1134/S181971241103010X

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