Effects of Semax on the Activity of Carboxypeptidase H
in Brain Regions and Adrenal Glands of Rats

V. B. Solov’ev^a,1, M. T. Gengin^a, T. N. Sollertinskaya^b, I. V. Latynova^a, and L. V. Zhivaeva^a

^aPenza State Pedagogical University, Penza, Russia

^bSechenov Institute of Evolutionary Physiology and Biochemistry, St. Petersburg, Russia

Received February 2, 2011

Abstract—We studied the effects of a single semax administration to rats on the activity of carboxypeptidase H,
a basic carboxypeptidase involved in the final stage of formation of biologically active peptides from their pre-
cursors. We found that the drug induced a long-term increase in the activity of carboxypeptidase, which lasted
for 24 h. We believe that this change in the activity of the enzyme studied may serve as one of the factors that
mediate semax action.

Keywords: semax, carboxypeptidase H, neuropeptides, brain, adrenal glands

DOI: 10.1134/S1819712411020115

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