Activation of Monoamine Oxidase as a Compensatory Response
during Ischemic Insult

M. G. Uzbekov^a,1, V. V. Alferova^b, E. Yu. Misionzhnik^a, and A. B. Gekht^b

^aMoscow Institute of Psychiatry, Moscow, Russia

^bDepartment of Neurology and Neurosurgery, Russian State Medical University, Moscow, Russia

Received January 2, 2011

Abstract—We measured the activity of monoamine oxidase (MAO) in platelets taken from 25 patients in the
acute period of ischemic hemispheric insult. The neurological deficit of the patients on arrival and discharge
from the hospital was evaluated using the data from clinical examinations and tests. In 64% of the patients with
ischemic insult, we found a considerable increase in the activity of platelet MAO on the 3rd–5th day of the
insult, as compared to the control group (P < 0.001). We found a correlation between the increase in MAO activ-
ity on the 3rd–5th day after ischemic insult and a decrease in neurological deficit on the 21st day after the insult.
The increase in the MAO activity during the acute period of ischemic insult is, presumably, one of compensa-
tory responses that develop during insult.

Keywords: monoamine oxidase of platelets, acute period of ischemic insult, neurological deficit, compensatory
response

DOI: 10.1134/S1819712411020127

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