M. V. Onufrieva,1, I. V. Savos’kinaa, I. L. Kaimovskiib, A. V. Lebedevab, E. I. Gusevb,
A. B. Guekhtb, and N. V. Gulyaevaa
aInstitute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia;
bRussian State Medical University, Moscow, Russia
Received September 11, 2010
Abstract—We studied the products of nitrosative stress, immunoglobulins, and autoantibodies to nitrated pro-
teins in the liquor of patients during the first day after stroke onset. The level of nitric oxide metabolites, nitrates,
and nitrites was significantly increased in the liquor of patients after ischemic stroke only. The activity of NO-
synthase and release of lactate dehydrogenase into the liquor after hemorrhagic stroke were significantly higher
as compared to those in the control group. In the liquor of patients, the content of immunoglobulins (Ig) of G,
M, and A classes was significantly elevated. Moreover, in the group with hemorrhagic stroke; the increase in
the level of these Igs was substantially higher as compared to the other groups. The elevation of nitrotyrosine-
BSA binding was significantly increased in the liquor of patients with both types of stroke. Thus, structural
modifications of proteins induced by nitrosative stress stimulate the immune response, which develops in the
liquor at the early stage of stroke.
Keywords: nitric oxide, nitrotyrosine, autoantibodies, nitrosative stress, stroke
DOI: 10.1134/S1819712411010077
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