on the Anxiety Behavior and Activity of the Pituitary
Adrenal System in Prenatally Stressed Male Rats
S. G. Pivina, Yu. O. Fedotova, V. K. Akulova, and N. E. Ordyan1
Laboratory of Neuroendocrinology, Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia
Received May 26, 2010
Abstract—We studied effects of the selective inhibitors of serotonin reuptake fluoxetine and paroxetine, which
were orally administered at a dose of 5.0 mg/kg from the 1st to 14th days of postnatal life, on the anxiety behav-
ior and hormonal stress reactivity of mature prenatally stressed male rats. We found that prenatal stress
decreased the anxiety level in mature male rats. Chronic treatment with paroxetine did not the alter the anxiety
behavior of prenatally stressed males. In contrast, treatment with fluoxetine had an anxiogenic effect on their
behavior, canceling the effect of prenatal stress on the anxiety behavior of male rats. Prenatal stress consider-
ably affected the dynamics of the stress response of the pituitary–adrenal system, which was seen as distur-
bances in the regulation of system feedback under conditions of stress-induced activation. Chronic administra-
tion of paroxetine or fluoxetine corrected the dynamics of stress-induced levels of corticosterone in the blood
of prenatally stressed males.
Key words: fluoxetine, paroxetine, anxiety, corticosterone, behavior, hormonal analysis, prenatal stress, male
rats
DOI: 10.1134/S1819712410041038
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