Characteristics of Oxidative Stress in Experimental Rat Brain
Ischemia Aggravated by Homocysteic Acid

I. S. Dobrotvorskaya^a,b,1, T. N. Fedorova^b, D. Dobrota^c, and T. T. Berezov^a

^aLaboratory of Biochemistry of Amines and Cyclic Nucleotides, Institute of Biomedical Chemistry,
Russian Academy of Medical Sciences, Moscow, Russia

^bLaboratory of Clinical and Experimental Neurochemistry, Research Centre of Neurology,
Russian Academy of Medical Sciences, Moscow, Russia

^cDepartment of Medical Biochemistry, Jesseinus Faculty of Medicine, Comenius University, Martin, Slovak Republic

Received June 2, 2010

Abstract—We developed a new experimental model of oxidative stress in rats, which combines the effects of
3-vessel brain ischemia and an increased level of homocysteine in blood circulation. We compared the protec-
tive effects of two compounds, the agonist of cannabinoid receptors Win5521-2 and the natural antioxidant car-
nosine. We found that Win5521-2 has a protective effect only at a normal blood level of homocysteine, whereas
carnosine is also effective under conditions of elevated homocysteine level.

Keywords: global brain ischemia, homocysteine, oxidative stress, carnosine, Win5521-2

DOI: 10.1134/S1819712410041014

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