Latent Periodicity Regions in Amino Acid Sequences

E. V. Korotkov¹, M. A. Korotkova², V. M. Rudenko¹, and K. G. Skryabin¹

¹ Bioengineering Center, Russian Academy Sciences, Moscow, 117312 Russia;
E-mail: korotkov@biengi.msk.su
² Moscow Engineering Physics Institute, Moscow, 115409 Russia

Received June 11, 1998

Abstract—We a propose mathematical approach to searching for latent periodicity in amino acid sequences.
The statistical significance of the latent periodicity was evaluated by the Monte Carlo method. Search for latent
periodicity in the SWISS-PROT bank sequences reveals over 10% proteins with latent periodicity including
enzymes. We present amino acid sequences with latent periodicity revealed in lipoamide dehydrogenase
(DLDH-AZOVI), asparagine synthase (ASN1-YEAST), endochitinase 2 (CHI2-COCIM), and Rho/Rac
effector (CTRO-MOUSE). These proteins feature latent periodicity regions 19, 6, 11, and 7 amino acid long,
respectively. The possible functional and evolutionary significance of the latent periodicity regions is discussed.

Key words: latent periodicity; reciprocal information; amino acid sequence

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