D. A. Domninskii1, L. V. Prokunina1, S. V. Kozyrev1, A. V. Budilov1, A. B. Poltaraus1,
E. R. Zabarovskii2, and V. M. Zakhar’ev1
1 Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 117984 Russia
2 Karolinska Institute, Stockholm, Sweden
Received November 13, 1998
Abstract—The nucleotide sequence of 300 NotI clones with short human genomic DNA inserts was deter-
mined. More that 70% clones corresponded to GC-rich genomic regions with clustered NotI sites. Presumably,
at least 10% of the NotI sites form clusters in the human genome. Inserts from 33 clones proved highly homol-
ogous to sequenced human genes and cDNAs. NotI clusters were assumed to be associated with genes involved
in regulating cell proliferation and differentiation.
Key words: human genome, NotI clones, sequencing
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