Functional Organization of CowpoxVirus Genome, Strain GRI-90. 3. Functions
of the Species-specific Left-Hand Region
P. F. Safronov, A. V. Totmenin, O. I. Ryazankina, and S. N. Shchelkunov
Institute of Molecular Biology, State Research Center of Virology and Biotechnology “Vector,” Kol’tsovo,
Novosibirsk Region, 633159 Russia
Received May 27, 1998
Abstract—Computer analysis of the variable left-hand region of the cowpox virus genome, strain GRI-90, was
done. Its structural–functional organization was compared with that of analogous genomic regions of vaccinia
virus (strains Copenhagen and Western Reserve) and smallpox (variola) virus (strains India-1967 and Garcia-
1966). Possible virulent factors encoded by the left-hand parts of orthopoxviral genomes, as well as viral pro-
tein families homologous to ankyrins and drosophila ring canal proteins, are considered in details. Evolutionary
relationships of cowpox, variola, and vaccinia viruses are discussed.
Key words: orthopoxviruses, cowpox virus, smallpox (variola) virus, vaccinia virus, genome, protein families,
virulence factors
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