D. A. Chistyakov1, R. I. Turakulov1, Ya.Yu. Kondrat’ev2, M. V. Shestakova2,
V. V. Nosikov1, I. I. Dedov2, and V. G. Debabov1
1 State Research Center GosNIIGenetika, Moscow, 113545 Russia
2 Endocrinology Research Center, Russian Academy of Medical Sciences, Moscow, 117036 Russia
Received August 21, 1998
Abstract—The T174M polymorphism (threonine (T) or methionine (M) in position 174 of the amino acid
sequence) of the angiotensinogen (AGT) gene was studied in patients with diabetes mellitus type 1 complicated
with diabetic nephropathy (DN) (n = 26) or not complicated (n = 42). As compared with controls, the frequency
of allele T in patients with DN was significantly lower (69.2% vs. 83.3%) and that of allele M was higher
(30.8% vs. 16.7%). An association between the AGT gene polymorphism and DN in diabetes mellitus type 1
was suggested for the Moscow population.
Key words: angiotensinogen gene, T174M polymorphism, diabetic nephropathy, insulin-dependent diabetes
mellitus, Moscow population
Pleiades Publishing home page | journal home page | top
If you have any problems with this server, contact webmaster.