E. L. Paiva-Oliveiraa, *, N. C. Limab, P. H. Silvab, N. T. A. Sousab, F. S. Barbosac,
M. Orsinid, and J. G. Silvad, e, **
a Department of Immunobiology, Institute of Biology, Neuroscience Master Science Program,
Fluminense Federal University (UFF), Niterói, RJ, Brazil
b Physiotherapy Course of Faculty of Minas (FAMINAS), Muriaé, MG, Brazil
c Department of Physiotherapy, Nilton Lins University Center (UNINILTONLINS), Manaus, AM, Brazil
d Department of Physiotherapy, Analysis of Human Movement Lab, Science of Rehabilitation Program, Augusto Motta
University Center (UNISUAM), Rio de Janeiro, RJ, Brazil
e Department of Physiotherapy, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil
*e-mail: eustaquiopaiva@hotmail.com
**e-mail: jglsilva@yahoo.com.br, jgsilva@hucff.ufrj.br
Received October 25, 2011; in final form, December 26, 2011; published online August 1, 2012
Abstract—Low level laser therapy (LLLT) has been suggested as an effective therapeutics in inflammatory
processes modulation and tissue repairing. However, there is a lack of studies that analyze the anti-inflamma-
tory effects of the infrared lasers in muscular skeletal injury. The aim of this study was to investigate the effects
of low-level laser therapy 904 nm in the repair process of skeletal muscle tissue. Swiss mice were submitted to
cryoinjury and divided in test (LLLT-treated) and control groups. Histological sections were stained with hema-
toxylin-eosin to assess general morphology and inflammatory influx, and Picrossirus to quantify collagen fibers
deposition. Our results showed significant reduction in inflammatory infiltrated in irradiated mice after 4 days
of treatment compared to control (p = 0.01). After 8 days, the irradiated group showed high levels at regenerat-
ing myofibers with significant statistically differences in relation at control group (p < 0.01). Collagen deposi-
tion was significantly increased in the final stages of regeneration at test group, when compared with control
group (p = 0.05). Our data suggests that LLLT reduces the inflammatory response in the initial stages of injury
and accelerates the process of muscular tissue repair.
DOI: 10.1134/S1054660X12090113
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