Optical Biopsy of Breast Cancer Tissue¹

M. S. AlSalhi^{a, d,} *, S. Ben Amer^b, K. Farhat^c, D. Rabah^c,
S. Devanesan^a, M. Atif^{a, f}, V. Masilamani^a, and Reem. K. S. Al-Dakheel^e

^a Research Chair on Laser Diagnosis of Cancers, King Saud University, Riyadh, KSA
^b King Faisal Research Centre, King Faisal Hospital Riyadh, KSA
^c Princess Johara Al-Ibrahim Research Centre for Prostate Cancer, College of Medicine,
King Khalid University Hospital, King Saud University Riyadh, KSA
^d Department of Physics and Astronomy, King Saud University, College of Science, Riyadh, KSA
^e Department of Physics and Astronomy, Dammam University, College of Science, Al-Khobar, KSA
^f National Institute of Laser and Optronics, Nilore, Islamabad, Pakistan

*e-mail: malsalhy@gmail.com

Received October 27, 2011; in final form November 2, 2011; published online July 9, 2012

Abstract—In this paper, we report results of Fluorescence Emission Spectra (FES) and Stokes Shift Spectra
(SSS) of 19 cancer tissue of invasive ductal carcinoma of different grades in comparison with normal breast
tissues (obtained away from tumor regions). We were able to get distinct differences in the spectral features of
normal and malignant tissues in terms of the ratios of concentrations of biomolecules like tryptophan, collagen
and NADH. The sensitivity and specificity were in the range of 75%. What was all the more important was the
parallelism in the spectral features of normal and malignant breast tissue pieces of above set of subjects. The
objective of our research is to evolve one such protocol and the first step is the spectral characterization of in
vitro optical analyses of excised tumor tissues.

DOI: 10.1134/S1054660X12080014

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