Qing Xiaoa, b, Jue Houa, b, and Ling Fua, b, *
a Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics-Huazhong University
of Science and Technology, 1037 Luoyu Rd., Wuhan 430074, China
b Key Laboratory of Biomedical Photonics of Ministry of Education, Huazhong University of Science and Technology,
1037 Luoyu Rd., Wuhan 430074, China
*e-mail: lfu@mail.hust.edu.cn
Received January 5, 2012; published online May 11, 2012
Abstract—A Fourier domain optical coherence tomography (OCT) system with 1310 nm light was demon-
strated to study inflammatory human skin and the skin coated with a moisturizer in vivo. By using a graphics
processing unit (GPU), the display rate could reach 20 frames/s with 1000 A-scans contained in one image. The
field of view (FOV) of the cross-sectional image is 7 mm in the lateral direction and the penetration depth is ~1
mm in skin. The result shows that, in inflammatory skin, the epidermis became thicker and had a decreased scat-
tering; furthermore, the region of the severe lesion present an uneven thickness of the epidermis compared with
the peripheral area. For the result of a finger tip coated with the moisturizer, the anti-reflection effect was sig-
nificant and the stratum corneum became more transparent. In this letter, we demonstrated that real-time display
with a large FOV could enable screening of a large tissue area; thereby increasing the dermatologic diagnostic
potential of the method by permitting a comparison of the lesion and the normal peripheral region.
DOI: 10.1134/S1054660X12060175
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