Application of Surface-Enhanced Raman
in Skin Cancer by Plasma¹

W. Z. Yin^a, Z. Y. Guo^a, Z. F. Zhuang^a, *, S. H. Liu^a, K. Xiong^b, and S. J. Chen^b

^a MOE Key Laboratory of Laser Life Science, Laboratory of Photonic Chinese Medicine of College Biophotonics,
South China Normal University, Guangzhou 510631, Guangdong, China

^b Southern Hospital, Southern Medical University, No. 1838, North Guangzhou Avenue, Guangzhou,
Guangdong, 510515 China

*e-mail: zhuangzhf@yahoo.com.cn

Received November 18, 2011; in final form, November 27, 2011; published online April 3, 2012

Abstract—We have developed a mouse squamous cell carcinomas (SCC) model by diniethylbenzanthracene
(DMBA) and ultraviolet (UVB). A silver colloid as SERS-active substrates is used for detecting the blood
plasma of mouse. The relative intensity of the band at 942 and 1499 cm^–1 is higher in SCC model than in healthy
one. Therefore, it can be used as an important “fingerprint” in order to diagnose these diseases. Results show
us how to get high signal-to-noise ratio of biological macromolecules surface-enhanced Raman scattering spec-
tra in blood plasma. And also offer useful help for understanding the rich molecular structure information in
biological tissues. It provides a molecular spectroscopy way for early detection of disease in blood plasma.

DOI: 10.1134/S1054660X12050349

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