Quantification of Glucose Levels in Flowing Blood Using M-
Mode Swept Source Optical Coherence Tomography1

H. Ullaha, b, *, B. Davoudib, A. Mariampillaic, G. Hussaind, M. Ikrama, and I. A. Vitkinb, e

a Department of Physics and Applied Mathematics, Pakistan Institute of Engineering and Applied Sciences,
Islamabad, 45650 Pakistan

b Department of Medical Biophysics, University of Toronto and Division of Biophysics and Bioimaging, Ontario Cancer
Institute/University Health Network, Toronto, Ontario, Canada

c Department of Electrical and Computer Engineering, Ryerson University, Toronto, Ontario, Canada

d National Institute of Lasers and Optronics, Islamabad, 45650 Pakistan

e Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada

*e-mail: hafeezullah79@gmail.com

Received November 5, 2011; in final form, November 12, 2011; published online March 6, 2012

Abstract—The increase of glucose levels in blood changes the viscosity of flowing fluids and shape of the
erythrocytes. Both of these can affect the details of light scattering as can be quantified via decorrelation times
measured by optical coherence tomography (OCT). The relative contributions of these competing effects have
been studied by examining the motion dynamics of deformable asymmetrical (red blood cells, RBCs with
~7m diameter and ~2 m thickness) and non deformable symmetrical (polystyrene microspheres, PSM with
1.4 m diameter) flowing scattering particles. The fluid flow under the action of gravity was modulated by
changing the glucose concentrations. Quantitative analysis of the OCT’s M-mode autocorrelation functions
enabled the derivations of the translational diffusion coefficients. These systematic studies are aimed at eventual
tissue imaging scenarios with speckle-variance OCT to obtain local glucose concentrations maps.

DOI: 10.1134/S1054660X12040251

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