A Non-Invasive Method for the Assessment of Hemostasis
in vivo by Using Dynamic Light Scattering¹

I. Fine^a, *, A. Kaminsky^a, **, B. Kuznik^b, ***, and L. Shenkman^c, ****

^a Elfi-Tech Ltd., Science Park, Rehovot, Israel

^b Chita State Medical Academy, Chita, Russia

^c Sackler School of Medicine, Tel Aviv University, Israel

*e-mail: ilyafine@elfi-tech.com
**e-mail: kaminskii@gmail.com
***e-mail: bi_kuznik@mail.ru
****e-mail: lshenk@post.tau.ac.il

Received June 23, 2011; in final form, September 20, 2011; published online December 28, 2011

Abstract—We present a new non-invasive method for assessing hemostasis in vivo. This method is based on
the analysis of the movement characteristics of red blood cells (RBCs) during blood stasis condition. Stasis is
intermittently induced by occlusion of arterial blood flow at the finger root. We assumed that under zero flow
conditions, RBC movement is driven mostly by Brownian motion, and we characterized the RBC movement
by utilizing the dynamic light scattering (DLS) technique in vivo. We found that during the stasis the RBCs
diffusion coefficient in plasma decreases. We speculate that the RBC diffusion coefficient is most strongly
related to endothelial and hemostatic activity. This assumption is supported by our findings that RBC move-
ment, being expressed through the characteristics of the measured DLS signal, is correlative to the biological
age and also is related to the coagulation factors. This new method can serve as a new diagnostic and research
tool for the assessment of hemostasis and vascular function.

DOI: 10.1134/S1054660X12020090

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