Aggregates of Au-NPs as SERS Label Created by Plasmon
Exciting
Hybrid-
Laser Mode1
R. Kumara, *, D. S. Mehtaa, **, S. Saraswatib, and C. Shakhera
a Laser Applications and Holography Laboratory, Instrument Design Development Centre Indian Institute of Technology
Delhi, Hauz Khas, New Delhi-110016, India
b Delhi Institute of Pharmaceutical Sciences and Research, University of Delhi-110017, India
*e-mail: kranjeet.iitd@gmail.com
**e-mail: dsmehta@iddc.iitd.ac.in
Received March 21, 2011; in final form, September 19, 2011; published online December 28, 2011
Abstract—Apart from commonly employed target-specific labeling/adsorption of antibodies over Au-NPs sur-
face for the creation of localized aggregates, an alternative approach using optical tweezers (OT) driven by
hybrid-
mode has been devised and exploited for in vitro detection of Ehrlich ascites carcinoma cells
(EAC) relying on enhanced scattering. Intra-cavity generated spatially featured asymmetric (SFA) laser beam
(
= 532 nm) has effected simultaneous trapping of mice-EAC cells and in-situ crowd/assembly of incubated
Au-NPs/small gold nano-aggregates (created from two or more individual Au-NPs). Relatively larger focus
spot created by tightly focused SFA beam than frequently employed Gaussian-mode in OT has offered an
extended working area and hence dilute heating has taken care of EAC cells. GNA improves significantly the
sensitivity of diagnostics relying on scattered light and the safety and efficacy of therapeutic nanotechnologies
for the diseases of cancer and vascular system in medicine.
10.1134/S1054660X12020120
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