N. A. Aksenovaa, *, T. Olesb, T. Sarnab, N. N. Glagoleva, A. V. Chernjakc, V. I. Volkovc,
S. L. Kotovaa, N. S. Melik-Nubarovd, and A. B. Solovievaa
a Semenov Institute of Chemical Physics RAS, ul. Kosygina 4, Moscow, 119991 Russia
b Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
c Institute of Problems of Chemical Physics RAS, prosp. Academika Semenova 1, Chernogolovka, 142432 Russia
d Moscow State University, Moscow, 119991 Russia
*e-mail: naksenova@mail.ru
Received April 4, 2012; published online September 3, 2012
Abstract—We have studied the effect of amphiphilic polymers with different structure (polyvinylpyrrolidone,
polyethyleneoxide and a triblock copolymer of ethylene- and propyleneoxide—(Pluronic F127)) on the photo-
activity of a hematoporphyrin derivative (dimegin). It has been shown that such polymers can cause a consid-
erable increase in the porphyrin photosensitizer (PPS) activity both in the process of singlet oxygen photoge-
neration and in the reaction of a substrate photooxidation in D2O and water. Among the studied polymers, poly-
vinylpyrrolidone appeared to have a most significant influence onto the photoactivity of dimegin. We attribute
the observed effect of the amphiphilic polymers on the photoactivity of dimegin to the presence of polymer-
porphyrin interactions resulting in the porphyrin disaggregation in aqueous phase. Using 1H NMR spectros-
copy, we have found that dimegin binds to the polymers via the PPS interaction mainly with the hydrophobic
fragments of polymeric macromolecules. However, in the case of polyvinylpyrrolidone we observed also PPS
interactions with the hydrophilic fragments of macromolecules.
DOI: 10.1134/S1054660X12100015
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