Tunable Fiber Laser Based Photoacoustic Spectrometer
for Breath Ammonia Analysis During Hemodialysis¹

J. W. Wang^a, *, H. Xie^b, L. R. Liang^a, W. Zhang^a, W. Peng^a, and Q. X. Yu^a, **

^a School of Physics and Optoelectronic Engineering, Dalian University of Technology,
Dalian, 116024 China

^b First Affiliated Hospital of Dalian Medical University, Dalian, 116011 China

*e-mail: w-jianwei@163.com

*e-mail: yuqx@dlut.edu.cn

Received July 7, 2011; in final form, August 22, 2011; published online November 28, 2011

Abstract—A photoacoustic (PA) spectrometer based on a near-IR tunable fiber laser is developed and used for
breath ammonia analysis. We successfully measured the breath ammonia level variation of six patients with
end-stage renal disease while they were undergoing hemodialysis in the hospital. The measurement results
showed that the initial concentration level of the breath ammonia were from 1600 to 2200 ppb before dialysis
treatment, the levels decreased to 200–600 ppb in the end stage of dialysis, which close to the levels of healthy
persons. Further improvement and applications of this PA spectrometer are discussed.

DOI: 10.1134/S1054660X12010227

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