Complexation of Lanthanide Cations with Ampicillin

V. G. Alekseev, M. V. Golubeva, and Yu. Ya. Yakubovich

Tver State University, ul. Zhelyabova 33, Tver, 170100 Russia

e-mail: Alekseev.Vladimir@tversu.ru

Received February 27, 2012

Abstract—The complexation of Ln³⁺ ions with ampicillin anions (Amp^–) in an aqueous solution at 25C has
been studied by pH titration on the background of 0.1 M KNO₃. Ln(OH)Amp⁺ complexes are formed in neutral
and weakly alkaline media. The logarithm of increases nonlinearly along the lanthanide series from 9.02
0.06 for Ce(OH)Amp⁺ to 10.25 0.09 for Lu(OH)Amp⁺. The structure of the Lu(OH)Amp⁺ complex was sim-
ulated by the PM6 semiempirical quantum-chemical method and the MOPAC 2009 software; the results of
which impliy the formation of a chelate complex via bidentate coordination of Amp^– through the oxygen atoms
of the carboxylate and -lactam groups and the inclusion of up to five water molecules into the coordination
sphere of Lu(III).

DOI: 10.1134/S0036023613050021

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