Crystal Structure and Biological Properties of a Tetranuclear
Zinc(II) Complex of Cysteamine, [Zn₄Cym₄Cl₄]
Prepared in the Presence of Diamines¹

M. Akhtar^a, M. Nawaz Tahir^b, M. Saleem^c, M. Mazhar^a,
A. Rauf^d, A. A. Isab^e, S. Ahmad^d, and S. Nadeem^a

^a Department of Chemistry, Quaid-i-Azam University, Islamabad, Pakistan

^b Department of Physics, University of Sargodha, Sargodha, Pakistan

^c Department of Civil Engineering, Jubail University College, P.O. Box 10074, Jubail Industrial City 31961, Saudi Arabia

^d Department of Chemistry, University of Engineering and Technology, Lahore 54890, Pakistan

^e Department of Chemistry, King Fahd University of Petroleum and Minerals, Dhahran 31261, Saudi Arabia

e-mail: saeed_a786@hotmail.com

Received November 20, 2014

Abstract—The reactions of ZnCl₂ and cysteamine hydrochloride (Cym-H · HCl) in the presence of diamines;
1,3-diaminopropane (dap) and tetramethylethylenediamine (tmen) yielded a Zn-cysteaminate complex,
[Zn₄Cym₄Cl₄] (1). In the similar reaction with cis-1,2-diaminocyclohxane (dach), a diamine complex,
[Zn(dach)Cl₂] (2) was obtained. The compounds, 1 and 2 were characterized by elemental analysis, IR and
NMR (¹H and ¹³C) spectroscopy. The crystal structure of 1 was determined by Xray crystallography. The struc-
ture of 1 shows that the complex exists in the form of a tetranuclear molecule in which zinc atoms are bridged
by S atoms of Cym forming an eight-membered ring. The complex consists of two crystallographically inde-
pendent Zn(II) ions. Zn1 and symmetry related ion are coordinated with two sulfur atoms and two nitrogen
atoms of Cym, while Zn2 and symmetry related ion exhibit a ZnS₂Cl₂ setup. In both coordination environments
zinc atom adopts a distorted tetrahedral geometry. Antimicrobial activities of the complex 1 were evaluated by
minimum inhibitory concentration and the results showed that the complex exhibited remarkable activities against
gram-negative bacteria (E. coli, P. aeruginosa) and yeasts (C.albicans, S. cerevisiae).

Keywords: zinc(II), cysteamine, diamines, x-ray structure, antimicrobial

DOI: 10.1134/S0036023615120037

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