Calcium Hydroxyapatite in Hydroxyapatite/Graphene
Oxide/Collagen Nanohybrids

N. A. Zakharov^a, Zh. A. Ezhova^a, E. M. Koval’^a,
A. G. Tkachev^b, and N. T. Kuznetsov^a

^a Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences,
Leninskii pr. 31, Moscow, 119991 Russia

^b Tambov State Technical University, Tambov, Russia

e-mail: zakharov@igic.ras.ru

Received March 12, 2015

Abstract—Interactions between calcium and phosphorus salts, graphene oxide (GO), and collagen (COL) in
aqueous solutions have been studied in the CaCl₂–(NH₄)₂HPO₄–NH₃–H₂O–GO–COL system (25C) using the
solubility (residual concentrations) method and pH measurements. Syntheses were shown to yield composites
comprising nanocrystalline calcium hydroxyapatite Ca₁₀(PO₄)₆(OH)₂) (HA), GO, and COL of empirical for-
mula Ca₁₀(PO₄)₆(OH)₂ xGO yH₂O zCOL (x = 0.5, 1.0, or 2.0; y = 6.5–7.7; z = 3 or 5 wt %). Some physic-
ochemical characteristics of synthesis products and the effects of the composite formulation on the crystallo-
graphic characteristics, sizes, and morphology of nanocrystalline hydroxyapatite (NCHA) were determined and
some composition–structure–dispersion–property relationships in the HA/GO/COL composites have been ana-
lyzed using chemical analysis, X-ray powder diffraction, IR spectroscopy, thermogravimetry (TGA), differen-
tial scanning calorimetry (DSC), and electron microscopy.

DOI: 10.1134/S0036023615120268

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