Application of Mesoporous COK-15 Metal-Organic Framework as Medication Carrier for Acetaminophen and Clindamycin

Abstract—In recent years, metal-organic frameworks (MOFs) have attracted considerable interest in a variety of fields, including catalysis, energy storage and conversion, gas storage and separation, sensing, and controlled drug delivery. COK-15 is a mesoporous MOF with substantially wide permanent pores, which make it a right candidate for drug delivery. In this work, the behavior of COK-15 as a medication carrier for entrapment of selected medications (acetaminophen and clindamycin) and then controlled releasing of the medications in a PBS (Phosphate Buffered Saline) solution is studied. COK-15 has been synthesized and characterized by X-ray powder diffraction, scanning electron microscope (SEM), Brunauer–Emmett–Teller (BET), Fourier-Transform Infrared spectroscopy (FT-IR), and thermogravimetric analysis (TGA). The medication releasing has been studied by UV-Vis technique at different time intervals. The release kinetics has been investigated by employing different kinetic models.