Scientific Foundations for the Creation of Antiviral
and Antibacterial Preparations

Paper by RAS Academician O. N. Chupakhin^a, RAS Academician V. N. Charushin^a,
and RAS Corresponding Member V. L. Rusinov^b*

^a Postovskii Institute of Organic Synthesis, Ural Branch, Russian Academy of Sciences, Yekaterinburg, Russia

^b Ural Federal University, Yekaterinburg, Russia

e-mail: chupakhin@ios.uran.ru, charushin@ios.uran.ru, v.rusinov@ios.uran.ru

Received January 22, 2016

Abstract—The results of the Ural scientific school’s organic chemists on the creation of antiviral and antibacte-
rial, including antitubercular, chemopreparations are considered. Basic research data were generalized on the syn-
thesis and study of antiviral activity and the establishment of the metabolism and mechanism of azoloazine series
compounds—azaanalogs of adenine and guanine, as well as their nucleosides, which led to the creation of a new
family of antiviral substances. One of them, triazavirin, has become a regular therapeutic fixture as an antiflu prep-
aration. The results of synthetic and biological studies on substituted pyrimidines, nucleosides of the benzimida-
zole and purine series, and other biologically active azaheterocycles are also discussed.

Keywords: triazavirin, triazide and other azoloazine derivatives, protein disulfide isomerase inhibitors, nucleo-
sides of fluorine-containing benzimidazoles and purines, antibacterial fluoroquinolones, bacterial DNA gyrase
inhibitors, kinetic resolution of intermediates, levofloxacin synthesis.

DOI: 10.1134/S1019331616030163

Pleiades Publishing home page | journal home page | top

If you have any problems with this server, contact webmaster.